5CTB
Humanized yeast ACC carboxyltransferase domain bound to 6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Summary for 5CTB
Entry DOI | 10.2210/pdb5ctb/pdb |
Related | 5CTC 5CTE |
Descriptor | Acetyl-CoA carboxylase, 6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one, SULFATE ION, ... (4 entities in total) |
Functional Keywords | acc, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) |
Cellular location | Cytoplasm: Q00955 |
Total number of polymer chains | 3 |
Total formula weight | 263353.27 |
Authors | Vajdos, F.F. (deposition date: 2015-07-23, release date: 2015-10-14, Last modification date: 2024-03-06) |
Primary citation | Kung, D.W.,Griffith, D.A.,Esler, W.P.,Vajdos, F.F.,Mathiowetz, A.M.,Doran, S.D.,Amor, P.A.,Bagley, S.W.,Banks, T.,Cabral, S.,Ford, K.,Garcia-Irizarry, C.N.,Landis, M.S.,Loomis, K.,McPherson, K.,Niosi, M.,Rockwell, K.L.,Rose, C.,Smith, A.C.,Southers, J.A.,Tapley, S.,Tu, M.,Valentine, J.J. Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase. Bioorg.Med.Chem.Lett., 25:5352-5356, 2015 Cited by PubMed: 26411795DOI: 10.1016/j.bmcl.2015.09.035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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