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PDB: 616 results
8P0D
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BU of 8p0d by Molmil
Human 14-3-3 sigma in complex with human MDM2 peptide
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Roversi, P, Ward, J, Doveston, R, Kwon, H, Romartinez Alonso, B.
Deposit date:2023-05-10
Release date:2024-02-21
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization.
J.Biol.Chem., 300, 2024
2C1J
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BU of 2c1j by Molmil
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3
Descriptor: 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE
Authors:Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C.
Deposit date:2005-09-15
Release date:2005-11-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3.
Mol.Cell, 20, 2005
2BR9
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BU of 2br9 by Molmil
14-3-3 Protein Epsilon (Human) Complexed to Peptide
Descriptor: 14-3-3 PROTEIN EPSILON, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS
Authors:Yang, X, Elkins, J.M, Soundararajan, M, Fedorov, O, Sundstrom, M, Edwards, A, Arrowsmith, C, Doyle, D.A.
Deposit date:2005-05-03
Release date:2005-05-12
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.
Proc.Natl.Acad.Sci.USA, 103, 2006
2BQ0
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BU of 2bq0 by Molmil
14-3-3 Protein Beta (Human)
Descriptor: 14-3-3 BETA/ALPHA
Authors:Yang, X, Elkins, J.M, Fedorov, O, Longman, E.J, Sobott, L, Ball, L.J, Sundstrom, M, Arrowsmith, C, Edwards, A, Doyle, D.A.
Deposit date:2005-04-26
Release date:2005-05-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.
Proc.Natl.Acad.Sci.USA, 103, 2006
2C63
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BU of 2c63 by Molmil
14-3-3 Protein Eta (Human) Complexed to Peptide
Descriptor: 14-3-3 PROTEIN ETA, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS
Authors:Elkins, J.M, Yang, X, Smee, C.E.A, Johansson, C, Sundstrom, M, Edwards, A, Weigelt, J, Arrowsmith, C, Doyle, D.A.
Deposit date:2005-11-07
Release date:2005-11-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.
Proc.Natl.Acad.Sci.USA, 103, 2006
2C74
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BU of 2c74 by Molmil
14-3-3 Protein Eta (Human) Complexed to Peptide
Descriptor: 14-3-3 PROTEIN ETA, CITRIC ACID, CONSENSUS PEPTIDE MODE 1 FOR 14-3-3 PROTEINS
Authors:Elkins, J.M, Yang, X, Smee, C.E.A, Johansson, C, Sundstrom, M, Edwards, A, Weigelt, J, Arrowsmith, C, Doyle, D.A.
Deposit date:2005-11-17
Release date:2005-12-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for protein-protein interactions in the 14-3-3 protein family.
Proc. Natl. Acad. Sci. U.S.A., 103, 2006
8Q1S
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BU of 8q1s by Molmil
Pathogenic mutations of human phosphorylation sites affect protein-protein interactions
Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein epsilon, BROMIDE ION, ...
Authors:Roske, Y, Daumke, O, Rrustemi, T, Selbach, M.
Deposit date:2023-08-01
Release date:2024-02-21
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Pathogenic mutations of human phosphorylation sites affect protein-protein interactions.
Nat Commun, 15, 2024
2C23
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BU of 2c23 by Molmil
14-3-3 Protein Beta (Human) in complex with exoenzyme S peptide
Descriptor: 14-3-3 BETA/ALPHA, EXOENZYME S PEPTIDE
Authors:Elkins, J.M, Schoch, G.A, Yang, X, Sundstrom, M, Arrowsmith, C, Edwards, A, Doyle, D.A.
Deposit date:2005-09-26
Release date:2005-09-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.
Proc.Natl.Acad.Sci.USA, 103, 2006
6QDR
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BU of 6qdr by Molmil
Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C.
Deposit date:2019-01-02
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.615 Å)
Cite:Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Cell Chem Biol, 27, 2020
2C1N
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BU of 2c1n by Molmil
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3
Descriptor: 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE
Authors:Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C.
Deposit date:2005-09-16
Release date:2005-11-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3.
Mol.Cell, 20, 2005
8QT5
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BU of 8qt5 by Molmil
Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1.
Descriptor: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION
Authors:Hothorn, M, Obergfell, E.
Deposit date:2023-10-12
Release date:2023-10-25
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis.
Plant Cell.Physiol., 2024
8QTC
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BU of 8qtc by Molmil
Crystal structure of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1.
Descriptor: 14-3-3-like protein GF14 omega, COBALT (II) ION, Protein BRASSINAZOLE-RESISTANT 1, ...
Authors:Hothorn, M, Obergfell, E.
Deposit date:2023-10-12
Release date:2023-11-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis.
Plant Cell.Physiol., 2024
8QTT
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BU of 8qtt by Molmil
Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the inhibitor protein BKI1.
Descriptor: 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, BRI1 kinase inhibitor 1, ...
Authors:Hothorn, M, Obergfell, E.
Deposit date:2023-10-13
Release date:2023-11-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis.
Plant Cell.Physiol., 2024
6QK8
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BU of 6qk8 by Molmil
Crystal structure of yeast 14-3-3 protein (Bmh1) from Saccharomyces cerevisiae with the Nha1p (yeast Na+/H+ antiporter) 14-3-3 binding motif Ser481
Descriptor: Na(+)/H(+) antiporter, Protein BMH1
Authors:Smidova, A, Obsil, T, Obsilova, V.
Deposit date:2019-01-28
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.917 Å)
Cite:The activity of Saccharomyces cerevisiae Na+, K+/H+antiporter Nha1 is negatively regulated by 14-3-3 protein binding at serine 481.
Biochim Biophys Acta Mol Cell Res, 1866, 2019
8QTF
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BU of 8qtf by Molmil
Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1.
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, ...
Authors:Hothorn, M, Obergfell, E.
Deposit date:2023-10-12
Release date:2023-11-22
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis.
Plant Cell.Physiol., 2024
6QHM
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BU of 6qhm by Molmil
14-3-3 sigma with RelA/p65 binding site pS281
Descriptor: 14-3-3 protein sigma, LEU-SEP-GLU
Authors:Wolter, M, Ottmann, C.
Deposit date:2019-01-16
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products.
J.Am.Chem.Soc., 142, 2020
6QDT
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BU of 6qdt by Molmil
Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C.
Deposit date:2019-01-02
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Cell Chem Biol, 27, 2020
2BTP
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BU of 2btp by Molmil
14-3-3 Protein Theta (Human) Complexed to Peptide
Descriptor: 14-3-3 PROTEIN TAU, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS
Authors:Elkins, J.M, Johansson, A.C.E, Smee, C, Yang, X, Sundstrom, M, Edwards, A, Arrowsmith, C, Doyle, D.A, Structural Genomics Consortium (SGC)
Deposit date:2005-06-05
Release date:2005-06-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.
Proc.Natl.Acad.Sci.USA, 103, 2006
6QDS
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BU of 6qds by Molmil
Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide stabilized by semi-synthetic fusicoccane FC-NCPC
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FC-NCPC, ...
Authors:Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C.
Deposit date:2019-01-02
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Cell Chem Biol, 27, 2020
4HKC
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BU of 4hkc by Molmil
14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide
Descriptor: 14-3-3 protein zeta/delta, GLYCEROL, alpha-4 integrin derived phosphorylated peptide
Authors:Bonet, R, Campbell, I.D.
Deposit date:2012-10-15
Release date:2013-06-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Characterization of 14-3-3-zeta Interactions with integrin tails
J.Mol.Biol., 425, 2013
3O8I
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BU of 3o8i by Molmil
Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment
Descriptor: 14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, 6,6-dihydroxy-1-methoxyhexan-2-one
Authors:Ottmann, C, Rose, R, Kaiser, M, Kuhenne, P.
Deposit date:2010-08-03
Release date:2010-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling
Mol.Cell.Biol., 30, 2010
4FJ3
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BU of 4fj3 by Molmil
14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide
Descriptor: 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase
Authors:Ottmann, C, Molzan, M.
Deposit date:2012-06-11
Release date:2012-09-05
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Synergistic binding of the phosphorylated S233- and S259-binding sites of C-RAF to one 14-3-3zeta dimer
J.Mol.Biol., 423, 2012
4GNT
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BU of 4gnt by Molmil
Complex of ChREBP and 14-3-3beta
Descriptor: 14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, SULFATE ION
Authors:Zhang, H, Huang, N.
Deposit date:2012-08-17
Release date:2012-10-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal Structure of Carbohydrate Response Element Binding Protein (ChREBP) in complex with 14-3-3b
To be Published
3P1S
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BU of 3p1s by Molmil
Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide and stabilizer fusicoccin A
Descriptor: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CHLORIDE ION, ...
Authors:Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C.
Deposit date:2010-09-30
Release date:2011-10-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
Chem. Biol., 20, 2013
3P1R
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BU of 3p1r by Molmil
Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide
Descriptor: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CALCIUM ION, ...
Authors:Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C.
Deposit date:2010-09-30
Release date:2011-10-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
Chem. Biol., 20, 2013

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PDB entries from 2024-08-14

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