3O8I

Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment

Summary for 3O8I

• Entry DOI: 10.2210/pdb3o8i/pdb
• Related: 1YWT 1YZ5 3CU8 3LW1
• Descriptor: 14-3-3 protein sigma, 14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase, 6,6-dihydroxy-1-methoxyhexan-2-one, ... (4 entities in total)
• Functional Keywords: protein-protein complex, 14-3-3, protein-protein interaction, phosphorylation, peptide binding protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P31947; Cytoplasm (By similarity): P04049
• Total number of polymer chains: 2
• Total formula weight: 28188.60

Authors

Ottmann, C.,Rose, R.,Kaiser, M.,Kuhenne, P. (deposition date: 2010-08-03, release date: 2010-09-29, Last modification date: 2023-11-01)

• Primary citation: Molzan, M.,Schumacher, B.,Ottmann, C.,Baljuls, A.,Polzien, L.,Weyand, M.,Thiel, P.,Rose, R.,Rose, M.,Kuhenne, P.,Kaiser, M.,Rapp, U.R.,Kuhlmann, J.,Ottmann, C.; Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling; Mol.Cell.Biol., 30:4698-4711, 2010; PubMed: 20679480; DOI: 10.1128/MCB.01636-09

Experimental method

X-RAY DIFFRACTION (2 Å)