3O8I
Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 14-3-3 protein sigma | polymer | 239 | 26818.2 | 1 | UniProt (P31947) Pfam (PF00244) In PDB | Homo sapiens (human) | Stratifin, Epithelial cell marker protein 1 |
| 2 | B | 14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase | polymer | 10 | 1208.2 | 1 | UniProt (P04049) In PDB | Proto-oncogene c-RAF, cRaf, Raf-1 | |
| 3 | A | 6,6-dihydroxy-1-methoxyhexan-2-one | non-polymer | 162.2 | 1 | Chemie (M1T) | |||
| 4 | water | water | 18.0 | 163 | Chemie (HOH) |
Sequence modifications
A: 1 - 231 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -7 | - | expression tag |
| Ala -6 | - | expression tag |
| Met -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28026.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 162.2 | |
| All* | Total formula weight | 28188.6 |
