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PDB: 4 results
3UBW
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BU of 3ubw by Molmil
Complex of 14-3-3 isoform epsilon, a Mlf1 phosphopeptide and a small fragment hit from a FBDD screen
Descriptor: (3S)-pyrrolidin-3-ol, 14-3-3 protein epsilon, Myeloid leukemia factor 1, ...
Authors:Molzan, M, Weyand, M, Rose, R, Ottmann, C.
Deposit date:2011-10-25
Release date:2012-01-25
Last modified:2012-02-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights of the MLF1/14-3-3 interaction.
Febs J., 279, 2012
4IEA
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BU of 4iea by Molmil
14-3-3 isoform sigma in complex with a phosphorylated C-RAF peptide
Descriptor: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase
Authors:Molzan, M, Ottmann, C.
Deposit date:2012-12-13
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers.
Acs Chem.Biol., 8, 2013
4IHL
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BU of 4ihl by Molmil
Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
Descriptor: (1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol, 14-3-3 protein zeta/delta, POTASSIUM ION, ...
Authors:Molzan, M, Ottmann, C.
Deposit date:2012-12-19
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers.
Acs Chem.Biol., 8, 2013
4FJ3
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BU of 4fj3 by Molmil
14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide
Descriptor: 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase
Authors:Ottmann, C, Molzan, M.
Deposit date:2012-06-11
Release date:2012-09-05
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Synergistic binding of the phosphorylated S233- and S259-binding sites of C-RAF to one 14-3-3zeta dimer
J.Mol.Biol., 423, 2012

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