5VO0
| Structure of a TRAF6-Ubc13~Ub complex | Descriptor: | POTASSIUM ION, TNF receptor-associated factor 6, Ubiquitin, ... | Authors: | Middleton, A.J, Day, C.L. | Deposit date: | 2017-05-01 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1. Nat Commun, 8, 2017
|
|
5VNZ
| Structure of a TRAF6-Ubc13~Ub complex | Descriptor: | TNF receptor-associated factor 6, Ubiquitin, Ubiquitin-conjugating enzyme E2 N, ... | Authors: | Middleton, A.J, Day, C.L. | Deposit date: | 2017-05-01 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.41 Å) | Cite: | The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1. Nat Commun, 8, 2017
|
|
4KBL
| Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism | Descriptor: | E3 ubiquitin-protein ligase ARIH1, ZINC ION | Authors: | Duda, D.M, Olszewski, J.L, Schulman, B.A. | Deposit date: | 2013-04-23 | Release date: | 2013-05-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism. Structure, 21, 2013
|
|
4KC9
| Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism | Descriptor: | E3 ubiquitin-protein ligase ARIH1, ZINC ION | Authors: | Duda, D.M, Olszewski, J.L, Schulman, B.A. | Deposit date: | 2013-04-24 | Release date: | 2013-05-29 | Last modified: | 2013-07-03 | Method: | X-RAY DIFFRACTION (3.603 Å) | Cite: | Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism. Structure, 21, 2013
|
|
6L8O
| Crystal structure of the K. lactis Rad5 (Hg-derivative) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA repair protein RAD5, MERCURY (II) ION | Authors: | Shen, M, Xiang, S. | Deposit date: | 2019-11-06 | Release date: | 2020-11-11 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun, 12, 2021
|
|
6L8N
| Crystal structure of the K. lactis Rad5 | Descriptor: | DNA repair protein RAD5, ZINC ION | Authors: | Shen, M, Xiang, S. | Deposit date: | 2019-11-06 | Release date: | 2020-11-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun, 12, 2021
|
|
5O76
| Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant | Descriptor: | CALCIUM ION, E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, ... | Authors: | Gabrielsen, M, Buetow, L, Huang, D.T. | Deposit date: | 2017-06-08 | Release date: | 2017-11-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.473 Å) | Cite: | A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants. Mol. Cell, 68, 2017
|
|
2Y1N
| Structure of c-Cbl-ZAP-70 peptide complex | Descriptor: | CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, ... | Authors: | Dou, H, Sibbet, G.J, Huang, D.T. | Deposit date: | 2010-12-08 | Release date: | 2012-01-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.999 Å) | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl. Nat.Struct.Mol.Biol., 19, 2012
|
|
2Y1M
| Structure of native c-Cbl | Descriptor: | CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION | Authors: | Dou, H, Sibbet, G.J, Huang, D.T. | Deposit date: | 2010-12-08 | Release date: | 2012-01-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl. Nat.Struct.Mol.Biol., 19, 2012
|
|
5OLM
| TRIM21 | Descriptor: | E3 ubiquitin-protein ligase TRIM21, ZINC ION | Authors: | James, L.C. | Deposit date: | 2017-07-28 | Release date: | 2018-04-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21. Elife, 7, 2018
|
|
7OIM
| Mouse RNF213, with mixed nucleotides bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, E3 ubiquitin-protein ligase RNF213, ... | Authors: | Grabarczyk, D, Ahel, J, Clausen, T. | Deposit date: | 2021-05-11 | Release date: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP To Be Published
|
|
7OIK
| |
6TAY
| Mouse RNF213 mutant R4753K modeling the Moyamoya-disease-related Human variant R4810K | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNF213,E3 ubiquitin-protein ligase RNF213,E3 ubiquitin-protein ligase RNF213, ... | Authors: | Ahel, J, Meinhart, A, Haselbach, D, Clausen, T. | Deposit date: | 2019-10-31 | Release date: | 2020-07-01 | Last modified: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism. Elife, 9, 2020
|
|
7ONI
| Structure of Neddylated CUL5 C-terminal region-RBX2-ARIH2* | Descriptor: | Cullin-5, E3 ubiquitin-protein ligase ARIH2, NEDD8, ... | Authors: | Kostrhon, S.P, prabu, J.R, Schulman, B.A. | Deposit date: | 2021-05-25 | Release date: | 2021-09-15 | Last modified: | 2021-10-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation. Nat.Chem.Biol., 17, 2021
|
|
6XNZ
| Structure of RAG1 (R848M/E649V)-RAG2-DNA Target Capture Complex | Descriptor: | 12RSS integration strand (34-mer), 12RSS non-integration strand (34-mer), 23RSS integration strand (45-mer), ... | Authors: | Zhang, Y, Corbett, E, Wu, S, Schatz, D.G. | Deposit date: | 2020-07-05 | Release date: | 2020-08-26 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase. Embo J., 39, 2020
|
|
6XNY
| Structure of RAG1 (R848M/E649V)-RAG2-DNA Strand Transfer Complex (Paired-Form) | Descriptor: | 12RSS integration strand (55-mer), 12RSS signal DNA top strand (34-mer), 23RSS integration strand (66-mer), ... | Authors: | Zhang, Y, Corbett, E, Wu, S, Schatz, D.G. | Deposit date: | 2020-07-05 | Release date: | 2020-08-26 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase. Embo J., 39, 2020
|
|
6XNX
| Structure of RAG1 (R848M/E649V)-RAG2-DNA Strand Transfer Complex (Dynamic-Form) | Descriptor: | 12RSS integration strand DNA (55-MER), 12RSS signal top strand DNA (34-MER), 23RSS integration strand DNA (66-MER), ... | Authors: | Zhang, Y, Corbett, E, Wu, S, Schatz, D.G. | Deposit date: | 2020-07-05 | Release date: | 2020-08-26 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase. Embo J., 39, 2020
|
|
4A4C
| Structure of phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex | Descriptor: | CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ... | Authors: | Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T. | Deposit date: | 2011-10-08 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.704 Å) | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl Nat.Struct.Mol.Biol., 19, 2012
|
|
4A4B
| Structure of modified phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex | Descriptor: | CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ... | Authors: | Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T. | Deposit date: | 2011-10-08 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.789 Å) | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl Nat.Struct.Mol.Biol., 19, 2012
|
|
6TAX
| Mouse RNF213 wild type protein | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNF213,E3 ubiquitin-protein ligase RNF213,E3 ubiquitin-protein ligase RNF213, ... | Authors: | Ahel, J, Meinhart, A, Haselbach, D, Clausen, T. | Deposit date: | 2019-10-31 | Release date: | 2020-07-01 | Last modified: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism. Elife, 9, 2020
|
|
6V0V
| Cryo-EM structure of mouse WT RAG1/2 NFC complex (DNA0) | Descriptor: | CALCIUM ION, DNA (30-MER), V(D)J recombination-activating protein 1, ... | Authors: | Chen, X, Yang, W, Gellert, M. | Deposit date: | 2019-11-19 | Release date: | 2020-01-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
|
|
8QNI
| |
8QNG
| |
8QNH
| Crystal structure of the E3 ubiquitin ligase Cbl-b with an allosteric inhibitor (WO2020264398 Ex23) | Descriptor: | 2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one, E3 ubiquitin-protein ligase CBL-B, SODIUM ION, ... | Authors: | Schimpl, M. | Deposit date: | 2023-09-26 | Release date: | 2023-11-22 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity. Acs Med.Chem.Lett., 14, 2023
|
|
5TTE
| Crystal Structure of an RBR E3 ubiquitin ligase in complex with an E2-Ub thioester intermediate mimic | Descriptor: | E3 ubiquitin-protein ligase ARIH1, Ubiquitin-conjugating enzyme E2 L3, ZINC ION, ... | Authors: | Yuan, L, Lv, Z, Olsen, S.K. | Deposit date: | 2016-11-03 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.501 Å) | Cite: | Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI. Nat Commun, 8, 2017
|
|