Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 608 results
4ROJ
DownloadVisualize
BU of 4roj by Molmil
Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide
Descriptor: Guanine nucleotide exchange factor VAV2, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION
Authors:Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2014-10-28
Release date:2014-12-10
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide
TO BE PUBLISHED
3KFJ
DownloadVisualize
BU of 3kfj by Molmil
Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic
Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ...
Authors:Clements, J.H.
Deposit date:2009-10-27
Release date:2010-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization.
J.Am.Chem.Soc., 131, 2009
7CIO
DownloadVisualize
BU of 7cio by Molmil
Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase
Descriptor: Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha
Authors:Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M.
Deposit date:2020-07-08
Release date:2020-12-09
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.
Mol.Immunol., 131, 2021
1MW4
DownloadVisualize
BU of 1mw4 by Molmil
Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139
Descriptor: Growth factor receptor-bound protein 7, Receptor protein-tyrosine kinase erbB-2
Authors:Ivancic, M, Lyons, B.A.
Deposit date:2002-09-27
Release date:2003-09-09
Last modified:2024-10-16
Method:SOLUTION NMR
Cite:Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2
J.BIOMOL.NMR, 27, 2003
6HTF
DownloadVisualize
BU of 6htf by Molmil
Crystal structure of human Btk SH2 domain bound to rF10 repebody
Descriptor: Tyrosine-protein kinase BTK, rF10 repebody
Authors:Duarte, D.P, Pojer, F, Hantschel, O.
Deposit date:2018-10-04
Release date:2020-05-20
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.
Nat Commun, 11, 2020
6E8K
DownloadVisualize
BU of 6e8k by Molmil
Legionella Longbeachae LeSH (Llo2327) bound to the human interleukin-2 receptor beta pTyr387 peptide
Descriptor: LeSH (Llo2327), interleukin-2 receptor beta pTyr387 peptide
Authors:Kaneko, T, Li, S.S.C.
Deposit date:2018-07-30
Release date:2018-11-14
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Identification and characterization of a large family of superbinding bacterial SH2 domains.
Nat Commun, 9, 2018
5KAZ
DownloadVisualize
BU of 5kaz by Molmil
Human SH2D1B structure
Descriptor: SH2 domain-containing protein 1B, SULFATE ION
Authors:Taha, M, Nezerwa, E, Nam, H.-J.
Deposit date:2016-06-02
Release date:2017-04-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The X-ray Crystallographic Structure of Human EAT2 (SH2D1B).
Protein Pept. Lett., 23, 2016
1WQU
DownloadVisualize
BU of 1wqu by Molmil
Solution structure of the human FES SH2 domain
Descriptor: Proto-oncogene tyrosine-protein kinase FES/FPS
Authors:Scott, A, Pantoja-Uceda, D, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Sugano, S, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-10-02
Release date:2005-06-14
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes
J.Biomol.NMR, 31, 2005
3C7I
DownloadVisualize
BU of 3c7i by Molmil
X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN.
Descriptor: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2R)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-valyl-L-aspartamide
Authors:Benfield, A.P, Martin, S.F.
Deposit date:2008-02-07
Release date:2008-08-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Ligand Preorganization May be Accompanied by Entropic Penalties in Protein-Ligand Interactions.
Angew.Chem.Int.Ed.Engl., 118, 2006
8CZ9
DownloadVisualize
BU of 8cz9 by Molmil
Crystal Structure of the E372K LNK SH2 Domain mutant in Complex with a JAK2 pY813 Phosphopeptide
Descriptor: CHLORIDE ION, JAK2 pY813 phosphopeptide, SH2B adapter protein 3
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-05-24
Release date:2023-05-31
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity.
J.Exp.Med., 221, 2024
2LCT
DownloadVisualize
BU of 2lct by Molmil
Solution structure of the Vav1 SH2 domain complexed with a Syk-derived doubly phosphorylated peptide
Descriptor: Proto-oncogene vav, Tyrosine-protein kinase SYK
Authors:Chen, C, Gorenstein, N, Post, C.
Deposit date:2011-05-09
Release date:2011-06-01
Last modified:2024-11-06
Method:SOLUTION NMR
Cite:Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav.
Mol.Cell.Biol., 31, 2011
2LNX
DownloadVisualize
BU of 2lnx by Molmil
Solution structure of Vav2 SH2 domain
Descriptor: Guanine nucleotide exchange factor VAV2
Authors:Wu, B, Zhang, J, Wu, J, Shi, Y.
Deposit date:2012-01-05
Release date:2012-11-21
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Identification and structural basis for a novel interaction between Vav2 and Arap3.
J.Struct.Biol., 180, 2012
6R5G
DownloadVisualize
BU of 6r5g by Molmil
C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1
Descriptor: ITSM, Tyrosine-protein phosphatase non-receptor type 11
Authors:Marasco, M.
Deposit date:2019-03-25
Release date:2020-02-05
Last modified:2024-10-09
Method:SOLUTION NMR
Cite:Molecular mechanism of SHP2 activation by PD-1 stimulation.
Sci Adv, 6, 2020
6ROZ
DownloadVisualize
BU of 6roz by Molmil
Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based switch motif
Descriptor: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based switch motif (ITSM)
Authors:Krausze, J, Sikorska, J, Carlomagno, T.
Deposit date:2019-05-13
Release date:2020-02-19
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Molecular mechanism of SHP2 activation by PD-1 stimulation.
Sci Adv, 6, 2020
5GJI
DownloadVisualize
BU of 5gji by Molmil
PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex
Descriptor: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION, ...
Authors:Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M.
Deposit date:2016-06-30
Release date:2016-12-14
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins
J. Biol. Chem., 292, 2017
5GJH
DownloadVisualize
BU of 5gjh by Molmil
Gads SH2 domain/CD28-derived peptide complex
Descriptor: GRB2-related adapter protein 2, T-cell-specific surface glycoprotein CD28
Authors:Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M.
Deposit date:2016-06-30
Release date:2016-12-14
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins
J. Biol. Chem., 292, 2017
5MTN
DownloadVisualize
BU of 5mtn by Molmil
Monobody Mb(Lck_1) bound to Lck-Sh2
Descriptor: Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck
Authors:Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
Deposit date:2017-01-10
Release date:2017-04-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
2MK2
DownloadVisualize
BU of 2mk2 by Molmil
Solution NMR structure of N-terminal domain (SH2 domain) of human Inositol polyphosphate phosphatase-like protein 1 (INPPL1) (fragment 20-117), Northeast Structural Genomics Consortium Target HR9134A
Descriptor: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Authors:Yang, Y, Ramelot, T.A, Janjua, H, Xiao, R, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG)
Deposit date:2014-01-23
Release date:2014-03-05
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution NMR structure of N-terminal domain (SH2 domain) of human Inositol polyphosphate phosphatase-like protein 1 (INPPL1) (fragment 20-117), Northeast Structural Genomics Consortium Target HR9134A.
To be Published
3EAZ
DownloadVisualize
BU of 3eaz by Molmil
Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), C122S mutant.
Descriptor: Tyrosine-protein kinase CSK
Authors:Liu, D, Seidel, R.D, Cowburn, D.
Deposit date:2008-08-26
Release date:2009-11-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase.
Biophys Rep, 2, 2016
5MTJ
DownloadVisualize
BU of 5mtj by Molmil
Yes1-SH2 in complex with monobody Mb(Yes_1)
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Monobody Mb(Yes_1), SULFATE ION, ...
Authors:Sha, F, Kukenshoner, T, Koide, S, Hantschel, O.
Deposit date:2017-01-09
Release date:2017-04-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
5MTM
DownloadVisualize
BU of 5mtm by Molmil
Monobody Mb(Lck_3) bound to Lck-SH2 domain
Descriptor: Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION
Authors:Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
Deposit date:2017-01-10
Release date:2017-04-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
6SM5
DownloadVisualize
BU of 6sm5 by Molmil
MbC/SHP1-C-SH2 complex
Descriptor: MbC (monobody targeting SHP1-C-SH2), Tyrosine-protein phosphatase non-receptor type 6
Authors:Mann, G, Hantschel, O.
Deposit date:2019-08-21
Release date:2021-01-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:MbC/SHP1-C-SH2 complex
To Be Published
6PXC
DownloadVisualize
BU of 6pxc by Molmil
N-Terminal SH2 domain of the p120RasGAP bound to a p190RhoGAP phosphotyrosine peptide
Descriptor: Ras GTPase-activating protein 1, phosphopeptide of p190RhoGAP
Authors:Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J.
Deposit date:2019-07-25
Release date:2019-12-18
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide.
Plos One, 14, 2019
6PXB
DownloadVisualize
BU of 6pxb by Molmil
N-Terminal SH2 domain of the p120RasGAP
Descriptor: Ras GTPase-activating protein 1
Authors:Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J.
Deposit date:2019-07-25
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.747 Å)
Cite:Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide.
Plos One, 14, 2019
6ROY
DownloadVisualize
BU of 6roy by Molmil
Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based inhibitory motif
Descriptor: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based inhibitory motif (ITIM)
Authors:Krausze, J, Sikorska, J, Carlomagno, T.
Deposit date:2019-05-13
Release date:2020-02-19
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular mechanism of SHP2 activation by PD-1 stimulation.
Sci Adv, 6, 2020

235458

PDB entries from 2025-04-30

PDB statisticsPDBj update infoContact PDBjnumon