6R5G

C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1

Summary for 6R5G

• Entry DOI: 10.2210/pdb6r5g/pdb
• NMR Information: BMRB: 34384
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11, ITSM (2 entities in total)
• Functional Keywords: shp-2 c-sh2 itsm sh2 domain pd-1 phosphotyrosine, peptide binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 14679.34

Authors

Marasco, M. (deposition date: 2019-03-25, release date: 2020-02-05, Last modification date: 2023-06-14)

• Primary citation: Marasco, M.,Berteotti, A.,Weyershaeuser, J.,Thorausch, N.,Sikorska, J.,Krausze, J.,Brandt, H.J.,Kirkpatrick, J.,Rios, P.,Schamel, W.W.,Kohn, M.,Carlomagno, T.; Molecular mechanism of SHP2 activation by PD-1 stimulation.; Sci Adv, 6:eaay4458-eaay4458, 2020; PubMed: 32064351; DOI: 10.1126/sciadv.aay4458

Experimental method

SOLUTION NMR