8CZ9

Crystal Structure of the E372K LNK SH2 Domain mutant in Complex with a JAK2 pY813 Phosphopeptide

Summary for 8CZ9

• Entry DOI: 10.2210/pdb8cz9/pdb
• Related: 7R8W 7R8X
• Descriptor: SH2B adapter protein 3, JAK2 pY813 phosphopeptide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: lnk, sh2b3, jak/stat, mpns, signaling protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 13676.09

Authors

Morris, R.,Kershaw, N.J.,Babon, J.J. (deposition date: 2022-05-24, release date: 2023-05-31, Last modification date: 2024-03-13)

• Primary citation: Zhang, Y.,Morris, R.,Brown, G.J.,Lorenzo, A.M.D.,Meng, X.,Kershaw, N.J.,Kiridena, P.,Burgio, G.,Gross, S.,Cappello, J.Y.,Shen, Q.,Wang, H.,Turnbull, C.,Lea-Henry, T.,Stanley, M.,Yu, Z.,Ballard, F.D.,Chuah, A.,Lee, J.C.,Hatch, A.M.,Enders, A.,Masters, S.L.,Headley, A.P.,Trnka, P.,Mallon, D.,Fletcher, J.T.,Walters, G.D.,Sestan, M.,Jelusic, M.,Cook, M.C.,Athanasopoulos, V.,Fulcher, D.A.,Babon, J.J.,Vinuesa, C.G.,Ellyard, J.I.; Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity.; J.Exp.Med., 221:-, 2024; PubMed: 38417019; DOI: 10.1084/jem.20221080

Experimental method

X-RAY DIFFRACTION (1.65 Å)