8CZ9
Crystal Structure of the E372K LNK SH2 Domain mutant in Complex with a JAK2 pY813 Phosphopeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SH2B adapter protein 3 | polymer | 110 | 12581.6 | 1 | UniProt (P50745) Pfam (PF00017) UniProt (by SIFTS) (O09039) | Mus musculus (house mouse) | Lymphocyte adapter protein,Lymphocyte-specific adapter protein Lnk,Signal transduction protein Lnk |
| 2 | B (C) | JAK2 pY813 phosphopeptide | polymer | 8 | 1059.0 | 1 | UniProt (by SIFTS) (O60674) | Homo sapiens | |
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D, E (A, C) | water | water | 18.0 | 76 | Chemie (HOH) |
Sequence modifications
A: 328 - 437 (UniProt: P50745)
| PDB | External Database | Details |
|---|---|---|
| Lys 372 | Glu 155 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 13640.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 35.5 | |
| All* | Total formula weight | 13676.1 |
