6ROZ

Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based switch motif

Summary for 6ROZ

Entry DOI	10.2210/pdb6roz/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based switch motif (ITSM) (2 entities in total)
Functional Keywords	phosphatase, inhibitory peptide, signal transducer, src homology-2 domains, cell cycle, itsm, immune receptor tyrosine-based switch motif
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	26335.33
Authors	Krausze, J.,Sikorska, J.,Carlomagno, T. (deposition date: 2019-05-13, release date: 2020-02-19, Last modification date: 2024-01-24)
Primary citation	Marasco, M.,Berteotti, A.,Weyershaeuser, J.,Thorausch, N.,Sikorska, J.,Krausze, J.,Brandt, H.J.,Kirkpatrick, J.,Rios, P.,Schamel, W.W.,Kohn, M.,Carlomagno, T. Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6:eaay4458-eaay4458, 2020 Cited by PubMed: 32064351 DOI: 10.1126/sciadv.aay4458 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.89 Å)

Structure validation