4B1Y
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![BU of 4b1y by Molmil](/molmil-images/mine/4b1y) | Structure of the Phactr1 RPEL-3 bound to G-actin | Descriptor: | ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Mouilleron, S, Wiezlak, M, O'Reilly, N, Treisman, R, McDonald, N.Q. | Deposit date: | 2012-07-12 | Release date: | 2013-07-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity. Structure, 20, 2012
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2FXU
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![BU of 2fxu by Molmil](/molmil-images/mine/2fxu) | X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Rizvi, S.A, Tereshko, V, Kossiakoff, A.A, Kozmin, S.A. | Deposit date: | 2006-02-06 | Release date: | 2006-03-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structure of bistramide a-actin complex at a 1.35 A resolution J.Am.Chem.Soc., 128, 2006
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4K41
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![BU of 4k41 by Molmil](/molmil-images/mine/4k41) | Crystal structure of actin in complex with marine macrolide kabiramide C | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Pereira, J.H, Petchprayoon, C, Moriarty, N.W, Fink, S.J, Cecere, G, Paterson, I, Adams, P.D, Marriott, G. | Deposit date: | 2013-04-11 | Release date: | 2014-10-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural and biochemical studies of actin in complex with synthetic macrolide tail analogues. Chemmedchem, 9, 2014
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1WUA
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![BU of 1wua by Molmil](/molmil-images/mine/1wua) | The structure of Aplyronine A-actin complex | Descriptor: | (8R,9R,10R,11R,14S,18S,20S,24S)-24-{(1R,2S,3R,6R,7R,8R,9S,10E)-8-(ACETYLOXY)-6-[(N,N-DIMETHYLALANYL)OXY]-11-[FORMYL(MET HYL)AMINO]-2-HYDROXY-1,3,7,9-TETRAMETHYLUNDEC-10-ENYL}-10-HYDROXY-14,20-DIMETHOXY-9,11,15,18-TETRAMETHYL-2-OXOOXACYCLOTE TRACOSA-3,5,15,21-TETRAEN-8-YL N,N,O-TRIMETHYLSERINATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Hirata, K, Muraoka, S, Suenaga, K, Kuroda, T, Kato, K, Tanaka, H, Yamamoto, M, Takata, M, Yamada, K, Kigoshi, H. | Deposit date: | 2004-12-03 | Release date: | 2006-02-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure basis for antitumor effect of aplyronine a J.Mol.Biol., 356, 2006
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2V52
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![BU of 2v52 by Molmil](/molmil-images/mine/2v52) | Structure of MAL-RPEL2 complexed to G-actin | Descriptor: | ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Mouilleron, S, Guettler, S, Langer, C.A, Treisman, R, McDonald, N.Q. | Deposit date: | 2008-10-01 | Release date: | 2008-11-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL. EMBO J., 27, 2008
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1QZ5
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![BU of 1qz5 by Molmil](/molmil-images/mine/1qz5) | Structure of rabbit actin in complex with kabiramide C | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Klenchin, V.A, Allingham, J.S, King, R, Tanaka, J, Marriott, G, Rayment, I. | Deposit date: | 2003-09-15 | Release date: | 2003-11-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin Nat.Struct.Biol., 10, 2003
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2Q0U
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![BU of 2q0u by Molmil](/molmil-images/mine/2q0u) | Structure of Pectenotoxin-2 and Latrunculin B Bound to Actin | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, CALCIUM ION, ... | Authors: | Allingham, J.S, Miles, C.O, Rayment, I. | Deposit date: | 2007-05-22 | Release date: | 2007-07-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | A structural basis for regulation of actin polymerization by pectenotoxins. J.Mol.Biol., 371, 2007
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3MN5
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![BU of 3mn5 by Molmil](/molmil-images/mine/3mn5) | Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Ducka, A.M, Sitar, T, Popowicz, G.M, Huber, R, Holak, T.A. | Deposit date: | 2010-04-21 | Release date: | 2010-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proc.Natl.Acad.Sci.USA, 107, 2010
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2PBD
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![BU of 2pbd by Molmil](/molmil-images/mine/2pbd) | Ternary complex of profilin-actin with the poly-PRO-GAB domain of VASP* | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Ferron, F, Rebowski, G, Dominguez, R. | Deposit date: | 2007-03-28 | Release date: | 2007-11-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP Embo J., 26, 2007
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5ZZA
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![BU of 5zza by Molmil](/molmil-images/mine/5zza) | OdinProfilin/Rabbit Actin Complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Robinson, R.C, Akil, C. | Deposit date: | 2018-05-31 | Release date: | 2018-10-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Genomes of Asgard archaea encode profilins that regulate actin. Nature, 562, 2018
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1J6Z
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![BU of 1j6z by Molmil](/molmil-images/mine/1j6z) | UNCOMPLEXED ACTIN | Descriptor: | ACTIN ALPHA 1, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | Authors: | Otterbein, L.R, Graceffa, P, Dominguez, R. | Deposit date: | 2001-05-15 | Release date: | 2001-08-15 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | The crystal structure of uncomplexed actin in the ADP state. Science, 293, 2001
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1S22
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![BU of 1s22 by Molmil](/molmil-images/mine/1s22) | Absolute Stereochemistry of Ulapualide A | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Allingham, J.S, Tanaka, J, Marriott, G, Rayment, I. | Deposit date: | 2004-01-07 | Release date: | 2004-02-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Absolute stereochemistry of ulapualide A Org.Lett., 6, 2004
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1QZ6
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![BU of 1qz6 by Molmil](/molmil-images/mine/1qz6) | Structure of rabbit actin in complex with jaspisamide A | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Klenchin, V.A, Allingham, J.S, King, R, Tanaka, J, Marriott, G, Rayment, I. | Deposit date: | 2003-09-15 | Release date: | 2003-11-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin Nat.Struct.Biol., 10, 2003
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2ASM
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![BU of 2asm by Molmil](/molmil-images/mine/2asm) | Structure of Rabbit Actin In Complex With Reidispongiolide A | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Allingham, J.S, Zampella, A, D'Auria, M.V, Rayment, I. | Deposit date: | 2005-08-23 | Release date: | 2005-10-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity Proc.Natl.Acad.Sci.Usa, 102, 2005
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2ASP
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![BU of 2asp by Molmil](/molmil-images/mine/2asp) | Structure of Rabbit Actin In Complex With Reidispongiolide C | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Allingham, J.S, Zampella, A, D'Auria, M.V, Rayment, I. | Deposit date: | 2005-08-23 | Release date: | 2005-10-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity Proc.Natl.Acad.Sci.Usa, 102, 2005
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8BJH
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![BU of 8bjh by Molmil](/molmil-images/mine/8bjh) | chimera of the inactive ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, with the double mutation K3528M and K3535I, fused to a proline-Rich-Domain (PRD) and profilin, bound to Latrunculin B-ADP-Mg-actin | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Actin, ... | Authors: | Teixeira-Nunes, M, Renault, L, Retailleau, P. | Deposit date: | 2022-11-04 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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8BJJ
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![BU of 8bjj by Molmil](/molmil-images/mine/8bjj) | ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to ATP-Mg-actin, human profilin 1 and a sulfate ion | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Teixeira-Nunes, M, Renault, L, Retailleau, P. | Deposit date: | 2022-11-04 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.699 Å) | Cite: | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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6W7V
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![BU of 6w7v by Molmil](/molmil-images/mine/6w7v) | Structure of rabbit actin in complex with truncated analog of Mycalolide B | Descriptor: | (1E,3R,4R,5S,6R,9S,10S,12S)-12-[(4-aminobutanoyl)oxy]-1-[ethyl(formyl)amino]-4,10-dimethoxy-3,5,9,13-tetramethyltetradec-1-en-6-yl (2R)-oxolane-2-carboxylate, 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Allingham, J.S, Deng, X, Trofimova, D. | Deposit date: | 2020-03-19 | Release date: | 2020-10-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Truncated Actin-Targeting Macrolide Derivative Blocks Cancer Cell Motility and Invasion of Extracellular Matrix. J.Am.Chem.Soc., 143, 2021
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2ASO
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![BU of 2aso by Molmil](/molmil-images/mine/2aso) | Structure of Rabbit Actin In Complex With Sphinxolide B | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Allingham, J.S, Zampella, A, D'Auria, M.V, Rayment, I. | Deposit date: | 2005-08-23 | Release date: | 2005-10-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity Proc.Natl.Acad.Sci.Usa, 102, 2005
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2Q0R
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![BU of 2q0r by Molmil](/molmil-images/mine/2q0r) | Structure of Pectenotoxin-2 Bound to Actin | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, CALCIUM ION, ... | Authors: | Allingham, J.S, Miles, C.O, Rayment, I. | Deposit date: | 2007-05-22 | Release date: | 2007-07-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A structural basis for regulation of actin polymerization by pectenotoxins. J.Mol.Biol., 371, 2007
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7C2G
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![BU of 7c2g by Molmil](/molmil-images/mine/7c2g) | |
6JH9
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![BU of 6jh9 by Molmil](/molmil-images/mine/6jh9) | |
8BJI
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![BU of 8bji by Molmil](/molmil-images/mine/8bji) | chimera of ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo fused to a proline-Rich-Domain (PRD) and profilin, bound to ADP-Mg-actin and a sulfate ion | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Actin, ... | Authors: | Teixeira-Nunes, M, Renault, L, Retailleau, P. | Deposit date: | 2022-11-04 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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4B1V
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![BU of 4b1v by Molmil](/molmil-images/mine/4b1v) | Structure of the Phactr1 RPEL-N domain bound to G-actin | Descriptor: | 1,2-ETHANEDIOL, ACTIN, ALPHA SKELETAL MUSCLE, ... | Authors: | Mouilleron, S, Wiezlak, M, O'Reilly, N, Treisman, R, McDonald, N.Q. | Deposit date: | 2012-07-12 | Release date: | 2012-11-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity. Structure, 20, 2012
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3SJH
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![BU of 3sjh by Molmil](/molmil-images/mine/3sjh) | Crystal Structure of a chimera containing the N-terminal domain (residues 8-29) of drosophila Ciboulot and the C-terminal domain (residues 18-44) of bovine Thymosin-beta4, bound to G-actin-ATP-Latrunculin A | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Renault, L, Husson, C, Carlier, M.F, Didry, D. | Deposit date: | 2011-06-21 | Release date: | 2012-01-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | How a single residue in individual beta-thymosin/WH2 domains controls their functions in actin assembly Embo J., 31, 2012
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