7SIY
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![BU of 7siy by Molmil](/molmil-images/mine/7siy) | cCBL TKB domain in complex with pZAP70 peptide | Descriptor: | E3 ubiquitin-protein ligase CBL, MAGNESIUM ION, Peptide from Tyrosine-protein kinase ZAP-70 | Authors: | Murray, J.M, Yu, C. | Deposit date: | 2021-10-15 | Release date: | 2022-11-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | cCBL TKB domain in complex with pZAP70 peptide To Be Published
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2OQ1
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![BU of 2oq1 by Molmil](/molmil-images/mine/2oq1) | Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide | Descriptor: | LEAD (II) ION, T-cell surface glycoprotein CD3 zeta chain, Tyrosine-protein kinase ZAP-70 | Authors: | Hatada, M.H, Laird, E.R, Green, J, Morgenstern, J, Ram, M.K. | Deposit date: | 2007-01-30 | Release date: | 2007-03-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular basis for the interaction of ZAP-70 with the T-cell receptor Nature, 377, 1995
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2Y1N
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![BU of 2y1n by Molmil](/molmil-images/mine/2y1n) | Structure of c-Cbl-ZAP-70 peptide complex | Descriptor: | CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, ... | Authors: | Dou, H, Sibbet, G.J, Huang, D.T. | Deposit date: | 2010-12-08 | Release date: | 2012-01-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.999 Å) | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl. Nat.Struct.Mol.Biol., 19, 2012
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4XZ0
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![BU of 4xz0 by Molmil](/molmil-images/mine/4xz0) | ZAP-70-tSH2:compound-A complex | Descriptor: | 1-(3-{5-[(3-chlorobenzyl)sulfonyl]-1H-tetrazol-1-yl}phenyl)ethanone, SULFATE ION, Tyrosine-protein kinase ZAP-70 | Authors: | Barros, T, Kuriyan, J, Visperas, P.R, Winger, J.A. | Deposit date: | 2015-02-03 | Release date: | 2015-06-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem. J., 465, 2015
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2CBL
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![BU of 2cbl by Molmil](/molmil-images/mine/2cbl) | N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE ON ZAP-70 | Descriptor: | CALCIUM ION, PROTO-ONCOGENE CBL, ZAP-70 | Authors: | Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J. | Deposit date: | 1998-08-28 | Release date: | 1999-05-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature, 398, 1999
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3ZNI
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![BU of 3zni by Molmil](/molmil-images/mine/3zni) | Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL-B, ... | Authors: | Dou, H, Buetow, L, Sibbet, G.J, Cameron, K, Huang, D.T. | Deposit date: | 2013-02-14 | Release date: | 2013-07-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Essentiality of a Non-Ring Element in Priming Donor Ubiquitin for Catalysis by a Monomeric E3. Nat.Struct.Mol.Biol., 20, 2013
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1U59
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![BU of 1u59 by Molmil](/molmil-images/mine/1u59) | Crystal Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine | Descriptor: | STAUROSPORINE, Tyrosine-protein kinase ZAP-70 | Authors: | Jin, L, Pluskey, S, Petrella, E.C, Cantin, S.M, Gorga, J.C, Rynkiewicz, M.J, Pandey, P, Strickler, J.E, Babine, R.E, Weaver, D.T, Seidl, K.J. | Deposit date: | 2004-07-27 | Release date: | 2004-08-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Three-dimensional Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine: IMPLICATIONS FOR THE DESIGN OF SELECTIVE INHIBITORS J.Biol.Chem., 279, 2004
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5O76
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![BU of 5o76 by Molmil](/molmil-images/mine/5o76) | Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant | Descriptor: | CALCIUM ION, E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, ... | Authors: | Gabrielsen, M, Buetow, L, Huang, D.T. | Deposit date: | 2017-06-08 | Release date: | 2017-11-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.473 Å) | Cite: | A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants. Mol. Cell, 68, 2017
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1M61
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![BU of 1m61 by Molmil](/molmil-images/mine/1m61) | |
2OZO
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![BU of 2ozo by Molmil](/molmil-images/mine/2ozo) | Autoinhibited intact human ZAP-70 | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase ZAP-70 | Authors: | Deindl, S, Kadlecek, T.A, Brdicka, T, Cao, X, Weiss, A, Kuriyan, J. | Deposit date: | 2007-02-26 | Release date: | 2007-05-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70. Cell(Cambridge,Mass.), 129, 2007
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4A4C
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![BU of 4a4c by Molmil](/molmil-images/mine/4a4c) | Structure of phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex | Descriptor: | CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ... | Authors: | Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T. | Deposit date: | 2011-10-08 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.704 Å) | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl Nat.Struct.Mol.Biol., 19, 2012
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4A4B
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![BU of 4a4b by Molmil](/molmil-images/mine/4a4b) | Structure of modified phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex | Descriptor: | CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ... | Authors: | Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T. | Deposit date: | 2011-10-08 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.789 Å) | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl Nat.Struct.Mol.Biol., 19, 2012
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4XZ1
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![BU of 4xz1 by Molmil](/molmil-images/mine/4xz1) | ZAP-70-tSH2:Compound-B adduct | Descriptor: | 2-[(7-chloro-4-nitro-2,1,3-benzoxadiazol-5-yl)amino]ethanol, Tyrosine-protein kinase ZAP-70, doubly phosphorylated ITAM peptide | Authors: | Barros, T, Kuriyan, J, Winger, J.A, Visperas, P.R. | Deposit date: | 2015-02-03 | Release date: | 2015-07-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem. J., 465, 2015
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1FBV
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![BU of 1fbv by Molmil](/molmil-images/mine/1fbv) | STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES | Descriptor: | SIGNAL TRANSDUCTION PROTEIN CBL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ... | Authors: | Zheng, N, Wang, P, Jeffrey, P.D, Pavletich, N.P. | Deposit date: | 2000-07-17 | Release date: | 2000-08-30 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell(Cambridge,Mass.), 102, 2000
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4K2R
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![BU of 4k2r by Molmil](/molmil-images/mine/4k2r) | Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Yan, Q, Barros, T, Visperas, P.R, Deindl, S, Kadlecek, T.A, Weiss, A, Kuriyan, J. | Deposit date: | 2013-04-09 | Release date: | 2013-05-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker. Mol.Cell.Biol., 33, 2013
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