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PDB: 18 results

7MW7
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Crystal structure of P1G mutant of D-dopachrome tautomerase
Descriptor: D-dopachrome decarboxylase, SODIUM ION, SULFATE ION
Authors:Manjula, R, Murphy, E.L, Murphy, J.W, Lolis, E.
Deposit date:2021-05-15
Release date:2021-08-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
3KAN
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BU of 3kan by Molmil
D-dopachrome tautomerase (D-DT)/macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP
Descriptor: 4-phenylpyrimidine, CHLORIDE ION, D-dopachrome tautomerase
Authors:Zierow, S, Lolis, E.
Deposit date:2009-10-19
Release date:2011-04-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment.
Faseb J., 28, 2014
8VFL
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Crystal Structure of WT D-Dopachrome Tautomerase (D-DT) at 290K
Descriptor: D-dopachrome decarboxylase
Authors:Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-21
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
8VG7
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Crystal Structure of T115A Variant of D-Dopachrome Tautomerase (D-DT)
Descriptor: D-dopachrome decarboxylase
Authors:Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-23
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
7MSE
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BU of 7mse by Molmil
High-resolution crystal structure of hMIF2 with tartrate at the active site
Descriptor: D-dopachrome decarboxylase, L(+)-TARTARIC ACID
Authors:Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E.
Deposit date:2021-05-11
Release date:2021-08-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
8VFN
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Crystal Structure of WT D-Dopachrome Tautomerase (D-DT) at 310K
Descriptor: D-dopachrome decarboxylase
Authors:Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-21
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
8DBB
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BU of 8dbb by Molmil
Crystal structure of DDT with the selective inhibitor 2,5-Pyridinedicarboxylic Acid
Descriptor: CITRIC ACID, D-dopachrome decarboxylase, pyridine-2,5-dicarboxylic acid
Authors:Parkins, A, Banumathi, S, Pantouris, G.
Deposit date:2022-06-14
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:2,5-Pyridinedicarboxylic acid is a bioactive and highly selective inhibitor of D-dopachrome tautomerase.
Structure, 31, 2023
8VFW
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Crystal Structure of V113N D-Dopachrome Tautomerase (D-DT)
Descriptor: CITRIC ACID, D-dopachrome decarboxylase
Authors:Parkins, A, Wolff, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-22
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
8VG8
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BU of 8vg8 by Molmil
Crystal Structure of T115A Variant of D-Dopachrome Tautomerase (D-DT) Bound to 4CPPC
Descriptor: 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid, D-dopachrome decarboxylase
Authors:Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-23
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
7MRU
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BU of 7mru by Molmil
Crystal structure of S62A MIF2 mutant
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, D-dopachrome decarboxylase
Authors:Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E.
Deposit date:2021-05-09
Release date:2021-08-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
8VFO
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Crystal Structure of L117G Variant of D-Dopachrome Tautomerase (D-DT)
Descriptor: CITRIC ACID, D-dopachrome decarboxylase
Authors:Parkins, A, Pilien, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-21
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
6C5F
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BU of 6c5f by Molmil
Human D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with the selective inhibitor 4-CPPC
Descriptor: 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid, D-dopachrome decarboxylase
Authors:Pantouris, G, Lolis, E.J.
Deposit date:2018-01-16
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor.
Biochemistry, 57, 2018
8VG5
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Crystal Structure of V113N Variant of D-Dopachrome Tautomerase (D-DT) Bound with 4CPPC
Descriptor: 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid, CITRIC ACID, D-dopachrome decarboxylase
Authors:Parkins, A, Pilien, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-22
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
1DPT
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BU of 1dpt by Molmil
D-DOPACHROME TAUTOMERASE
Descriptor: D-DOPACHROME TAUTOMERASE
Authors:Sugimoto, H, Taniguchi, M, Nakagawa, A, Tanaka, I.
Deposit date:1998-05-11
Release date:1999-03-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution.
Biochemistry, 38, 1999
7MRV
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BU of 7mrv by Molmil
F100A mutant structure of MIF2 (D-DT)
Descriptor: D-dopachrome decarboxylase, SULFATE ION
Authors:Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E.
Deposit date:2021-05-09
Release date:2021-08-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
8VFK
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BU of 8vfk by Molmil
Crystal Structure of Delta 109-117 D-Dopachrome Tautomerase (D-DT)
Descriptor: CITRATE ANION, D-dopachrome decarboxylase, SODIUM ION
Authors:Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-21
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
4Q3F
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Human D-DT complexed with tartrate
Descriptor: D-dopachrome decarboxylase, L(+)-TARTARIC ACID
Authors:Rajasekaran, D, Lolis, E.
Deposit date:2014-04-11
Release date:2014-06-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment.
Faseb J., 28, 2014
8VDY
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Crystal Structure of Delta 114-117 D-Dopachrome Tautomerase (D-DT)
Descriptor: D-dopachrome decarboxylase
Authors:Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-18
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024

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