8DBB

Crystal structure of DDT with the selective inhibitor 2,5-Pyridinedicarboxylic Acid

Summary for 8DBB

Entry DOI	10.2210/pdb8dbb/pdb
Descriptor	D-dopachrome decarboxylase, pyridine-2,5-dicarboxylic acid, CITRIC ACID, ... (4 entities in total)
Functional Keywords	trimeric, inhibitor, complex, enzyme, lyase-inhibitor complex, lyase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	38867.65
Authors	Parkins, A.,Banumathi, S.,Pantouris, G. (deposition date: 2022-06-14, release date: 2023-03-08, Last modification date: 2023-10-25)
Primary citation	Parkins, A.,Das, P.,Prahaladan, V.,Rangel, V.M.,Xue, L.,Sankaran, B.,Bhandari, V.,Pantouris, G. 2,5-Pyridinedicarboxylic acid is a bioactive and highly selective inhibitor of D-dopachrome tautomerase. Structure, 31:355-, 2023 Cited by PubMed: 36805127 DOI: 10.1016/j.str.2023.01.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation