6JBQ
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6VJS
| Escherichia coli RNA polymerase and ureidothiophene-2-carboxylic acid complex | Descriptor: | 3-{[benzyl(ethyl)carbamoyl]amino}-5-(4-phenoxyphenyl)thiophene-2-carboxylic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Murakami, K.S, Molodtsov, V. | Deposit date: | 2020-01-17 | Release date: | 2020-10-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.02 Å) | Cite: | Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus -Based Wound Infection Model in SKH1 Mice. Acs Infect Dis., 6, 2020
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6P1K
| Cryo-EM structure of Escherichia coli sigma70 bound RNAP polymerase holoenzyme | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | Deposit date: | 2019-05-20 | Release date: | 2020-02-26 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.05 Å) | Cite: | E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation. Elife, 8, 2019
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6UTX
| E. coli sigma-S transcription initiation complex with an empty bubble ("Old" crystal) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zuo, Y, De, S, Steitz, T.A. | Deposit date: | 2019-10-30 | Release date: | 2020-08-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.05 Å) | Cite: | Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
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8AC1
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6JNX
| Cryo-EM structure of a Q-engaged arrested complex | Descriptor: | Antiterminator Q protein, DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Feng, Y, Shi, J. | Deposit date: | 2019-03-18 | Release date: | 2019-06-12 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.08 Å) | Cite: | Structural basis of Q-dependent transcription antitermination. Nat Commun, 10, 2019
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4ZH3
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6UUC
| E. coli sigma-S transcription initiation complex with a 3-nt RNA and a mismatching ATP ("Fresh" crystal soaked with ATP for 2 hours) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Zuo, Y, De, S, Steitz, T.A. | Deposit date: | 2019-10-30 | Release date: | 2020-08-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.096 Å) | Cite: | Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
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6UU1
| E. coli sigma-S transcription initiation complex with a 4-nt RNA and a CTP ("Fresh" crystal soaked with CTP, GTP, and ddTTP for 30 minutes) | Descriptor: | CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Zuo, Y, De, S, Steitz, T.A. | Deposit date: | 2019-10-30 | Release date: | 2020-08-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.097 Å) | Cite: | Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
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6ALF
| CryoEM structure of crosslinked E.coli RNA polymerase elongation complex | Descriptor: | DNA (29-MER), DNA (5'-D(*GP*GP*GP*CP*TP*AP*AP*TP*GP*AP*CP*GP*GP*CP*GP*AP*AP*TP*AP*CP*CP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Kang, J.Y, Darst, S.A. | Deposit date: | 2017-08-07 | Release date: | 2017-08-16 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of transcription arrest by coliphage HK022 Nun in anEscherichia coliRNA polymerase elongation complex. Elife, 6, 2017
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6XH8
| CueR-transcription activation complex with RNA transcript | Descriptor: | COPPER (II) ION, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Liu, B, Shi, W, Yang, Y. | Deposit date: | 2020-06-18 | Release date: | 2021-04-14 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of copper-efflux-regulator-dependent transcription activation. Iscience, 24, 2021
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8E6Z
| Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, dC75 rut mimic RNA, Mg-ADP-BeF3, and NusG; TEC part | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Wang, C, Ebright, R.H. | Deposit date: | 2022-08-23 | Release date: | 2022-09-07 | Last modified: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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7PYK
| CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA (NusA elongation complex in more-swiveled conformation) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-10 | Release date: | 2022-03-23 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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7PY7
| CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA and NusG (NusA and NusG elongation complex in more-swiveled conformation) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-09 | Release date: | 2022-03-23 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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7PY6
| CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA and NusG (NusA and NusG elongation complex in less-swiveled conformation) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhu, C, Guo, X, Weixlbaumer, A. | Deposit date: | 2021-10-09 | Release date: | 2022-03-23 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Transcription factors modulate RNA polymerase conformational equilibrium. Nat Commun, 13, 2022
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5UAH
| Escherichia coli RNA polymerase and Rifampin complex, RpoB D516V mutant | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S. | Deposit date: | 2016-12-19 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis. Mol. Microbiol., 103, 2017
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6VZJ
| Escherichia coli transcription-translation complex A1 (TTC-A1) containing mRNA with a 15 nt long spacer, fMet-tRNAs at E-site and P-site, and lacking transcription factor NusG | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ... | Authors: | Molodtsov, V, Wang, C, Su, M, Ebright, R.H. | Deposit date: | 2020-02-28 | Release date: | 2020-09-02 | Last modified: | 2020-09-23 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of transcription-translation coupling. Science, 369, 2020
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6Z9R
| Transcription termination intermediate complex 3 | Descriptor: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Said, N, Hilal, T, Loll, B, Wahl, M.C. | Deposit date: | 2020-06-04 | Release date: | 2020-11-04 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho. Science, 371, 2021
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6FLP
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6Z9T
| Transcription termination intermediate complex 5 | Descriptor: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Said, N, Hilal, T, Loll, B, Wahl, M.C. | Deposit date: | 2020-06-04 | Release date: | 2020-11-04 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho. Science, 371, 2021
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6X26
| Mfd-bound E.coli RNA polymerase elongation complex - L1 state | Descriptor: | DNA (64-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A. | Deposit date: | 2020-05-20 | Release date: | 2021-02-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
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8AC0
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8AD1
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6GH6
| Cryo-EM structure of bacterial RNA polymerase-sigma54 holoenzyme intermediate partially loaded complex | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Glyde, R, Ye, F.Z, Zhang, X.D. | Deposit date: | 2018-05-04 | Release date: | 2018-07-04 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structures of Bacterial RNA Polymerase Complexes Reveal the Mechanism of DNA Loading and Transcription Initiation. Mol. Cell, 70, 2018
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6CUX
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