1WA3
 
 | | Mechanism of the Class I KDPG aldolase | | Descriptor: | 2-KETO-3-DEOXY-6-PHOSPHOGLUCONATE ALDOLASE, PYRUVIC ACID, SULFATE ION | | Authors: | Fullerton, S.W.B, Griffiths, J.S, Merkel, A.B, Wymer, N.J, Hutchins, M.J, Fierke, C.A, Toone, E.J, Naismith, J.H. | | Deposit date: | 2004-10-22 | | Release date: | 2005-01-26 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Mechanism of the Class I Kdpg Aldolase.
Bioorg.Med.Chem., 14, 2006
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1VLW
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5OMI
 | | Crystal structure of GP2 from Lassa virus in a post fusion conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Pre-glycoprotein polyprotein GP complex, ... | | Authors: | Shulman, A, Diskin, R. | | Deposit date: | 2017-07-31 | | Release date: | 2018-08-29 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Variations in Core Packing of GP2 from Old World Mammarenaviruses in their Post-Fusion Conformations Affect Membrane-Fusion Efficiencies.
J.Mol.Biol., 431, 2019
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4ZJF
 | | Crystal structure of GP1 - the receptor binding domain of Lassa virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein | | Authors: | Cohen-Dvashi, H, Cohen, N, Israeli, H, Diskin, R. | | Deposit date: | 2015-04-29 | | Release date: | 2015-05-27 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.595 Å) | | Cite: | Molecular Mechanism for LAMP1 Recognition by Lassa Virus.
J.Virol., 89, 2015
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7S8H
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7UOV
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7UOT
 | | Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 37.2D heavy chain (variable domain), ... | | Authors: | Li, H, Saphire, E.O. | | Deposit date: | 2022-04-13 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus.
Sci Transl Med, 14, 2022
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7TYV
 | | Structure of Lassa Virus glycoprotein (Josiah) bound to Fab 25.10C | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 25.10C Fab Heavy Chain, ... | | Authors: | Enriquez, A.S, Hastie, K.M. | | Deposit date: | 2022-02-14 | | Release date: | 2022-06-01 | | Last modified: | 2022-06-15 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Delineating the mechanism of anti-Lassa virus GPC-A neutralizing antibodies.
Cell Rep, 39, 2022
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8SZZ
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8TVB
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5VK2
 | | Structural basis for antibody-mediated neutralization of Lassa virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Hastie, K.M, Zandonatti, M.A, Kleinfelter, L.M, Rowland, M.L, Rowland, M.M, Chandra, K, Branco, L.M, Robinson, J.E, Garry, R.F, Saphire, E.O. | | Deposit date: | 2017-04-20 | | Release date: | 2017-05-31 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.201 Å) | | Cite: | Structural basis for antibody-mediated neutralization of Lassa virus.
Science, 356, 2017
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8EJJ
 | | Lassa virus glycoprotein complex (Josiah) bound to S370.7 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Perrett, H.R, Ward, A.B. | | Deposit date: | 2022-09-16 | | Release date: | 2023-06-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies.
Cell Rep, 42, 2023
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7PUY
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8TYC
 | | Lassa GPC (strain Josiah) bound to rabbit polyclonal base-targeting antibody Base-1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Perrett, H.R, Brouwer, P.J.M, Ward, A.B. | | Deposit date: | 2023-08-24 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Mapping of vaccine-induced humoral responses to the Lassa virus glycoprotein reveals off-target and immunodominant responses
To Be Published
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6JGY
 | | Crystal structure of LASV-GP2 in a post fusion conformation | | Descriptor: | Pre-glycoprotein polyprotein GP complex | | Authors: | Zhu, Y, Zhang, X, Chen, B, Ye, S, Zhang, R. | | Deposit date: | 2019-02-15 | | Release date: | 2019-09-11 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.389 Å) | | Cite: | Crystal Structure of Refolding Fusion Core of Lassa Virus GP2 and Design of Lassa Virus Fusion Inhibitors.
Front Microbiol, 10, 2019
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8E01
 | | Structure of engineered nano-cage fusion protein | | Descriptor: | 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase | | Authors: | Moustafa, I.M, Hafenstein, S.L. | | Deposit date: | 2022-08-08 | | Release date: | 2022-11-16 | | Last modified: | 2022-12-28 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model.
Biorxiv, 2022
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8JGC
 | | Cryo-EM structure of Mi3 fused with LOV2 | | Descriptor: | LOV domain-containing protein,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase | | Authors: | Zhang, H.W, Kang, W, Xue, C. | | Deposit date: | 2023-05-20 | | Release date: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Dynamic Metabolons Using Stimuli-Responsive Protein Cages.
J.Am.Chem.Soc., 146, 2024
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6P95
 | | Structure of Lassa virus glycoprotein in complex with Fab 25.6A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Saphire, E.O, Hastie, K.M. | | Deposit date: | 2019-06-09 | | Release date: | 2019-09-11 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization.
Cell, 178, 2019
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8JGA
 | | Cryo-EM structure of Mi3 fused with FKBP | | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1A,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase | | Authors: | Zhang, H.W, Kang, W, Xue, C. | | Deposit date: | 2023-05-20 | | Release date: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.68 Å) | | Cite: | Dynamic Metabolons Using Stimuli-Responsive Protein Cages.
J.Am.Chem.Soc., 146, 2024
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7B3Y
 | | Structure of a nanoparticle for a COVID-19 vaccine candidate | | Descriptor: | Fibronectin binding protein,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase | | Authors: | Duyvesteyn, H.M.E, Stuart, D.I. | | Deposit date: | 2020-12-01 | | Release date: | 2021-01-13 | | Last modified: | 2021-02-03 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses.
Nat Commun, 12, 2021
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7PVD
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8EJH
 | | Lassa virus glycoprotein complex (Josiah) bound to 12.1F Fab | | Descriptor: | 12.1F Fab heavy chain, 12.1F Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Perrett, H.R, Ward, A.B. | | Deposit date: | 2022-09-16 | | Release date: | 2023-06-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies.
Cell Rep, 42, 2023
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8EJF
 | | Structure of lineage V Lassa virus glycoprotein complex (strain Soromba-R) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Perrett, H.R, Ward, A.B. | | Deposit date: | 2022-09-16 | | Release date: | 2023-06-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.72 Å) | | Cite: | Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies.
Cell Rep, 42, 2023
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8EJD
 | | Structure of lineage IV Lassa virus glycoprotein complex (strain Josiah) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Perrett, H.R, Ward, A.B. | | Deposit date: | 2022-09-16 | | Release date: | 2023-06-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies.
Cell Rep, 42, 2023
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8TYE
 | | Lassa GPC (strain Josiah) bound to rabbit polyclonal fusion-peptide-targeting antibody FP-1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Perrett, H.R, Brouwer, P.J.M, Ward, A.B. | | Deposit date: | 2023-08-25 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses
To Be Published
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