7B3Y

Structure of a nanoparticle for a COVID-19 vaccine candidate

Summary for 7B3Y

• Entry DOI: 10.2210/pdb7b3y/pdb
• EMDB information: 11997
• Descriptor: Fibronectin binding protein,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (1 entity in total)
• Functional Keywords: sars-cov-2, spytag, vlp, receptor-binding domain, vaccine, covid-19, spycatcher, nanocage, icosahedral, nanoparticle, coronavirus, mi3, virus like particle
• Biological source: Streptococcus pyogenes serotype M49 (strain NZ131); More
• Total number of polymer chains: 1
• Total formula weight: 36000.71

Authors

Duyvesteyn, H.M.E.,Stuart, D.I. (deposition date: 2020-12-01, release date: 2021-01-13, Last modification date: 2021-02-03)

• Primary citation: Tan, T.K.,Rijal, P.,Rahikainen, R.,Keeble, A.H.,Schimanski, L.,Hussain, S.,Harvey, R.,Hayes, J.W.P.,Edwards, J.C.,McLean, R.K.,Martini, V.,Pedrera, M.,Thakur, N.,Conceicao, C.,Dietrich, I.,Shelton, H.,Ludi, A.,Wilsden, G.,Browning, C.,Zagrajek, A.K.,Bialy, D.,Bhat, S.,Stevenson-Leggett, P.,Hollinghurst, P.,Tully, M.,Moffat, K.,Chiu, C.,Waters, R.,Gray, A.,Azhar, M.,Mioulet, V.,Newman, J.,Asfor, A.S.,Burman, A.,Crossley, S.,Hammond, J.A.,Tchilian, E.,Charleston, B.,Bailey, D.,Tuthill, T.J.,Graham, S.P.,Duyvesteyn, H.M.E.,Malinauskas, T.,Huo, J.,Tree, J.A.,Buttigieg, K.R.,Owens, R.J.,Carroll, M.W.,Daniels, R.S.,McCauley, J.W.,Stuart, D.I.,Huang, K.A.,Howarth, M.,Townsend, A.R.; A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses.; Nat Commun, 12:542-542, 2021; PubMed: 33483491; DOI: 10.1038/s41467-020-20654-7

Experimental method

ELECTRON MICROSCOPY (3.7 Å)