4OZ1
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7SN6
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![BU of 7sn6 by Molmil](/molmil-images/mine/7sn6) | U2AF65 UHM BOUND TO SF3B155 ULM5 | Descriptor: | ISOPROPYL ALCOHOL, Splicing factor 3B subunit 1, Splicing factor U2AF 65 kDa subunit | Authors: | Loerch, S, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2021-10-27 | Release date: | 2022-07-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A UHM-ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing. J.Biol.Chem., 298, 2022
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6N3E
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![BU of 6n3e by Molmil](/molmil-images/mine/6n3e) | Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4 | Descriptor: | FORMIC ACID, GLYCEROL, HIV Tat-specific factor 1, ... | Authors: | Loerch, S, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2018-11-15 | Release date: | 2019-01-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.893 Å) | Cite: | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
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6N3F
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![BU of 6n3f by Molmil](/molmil-images/mine/6n3f) | Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5 | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, HIV Tat-specific factor 1, ... | Authors: | Leach, J.R, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2018-11-15 | Release date: | 2019-01-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
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7Q4O
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![BU of 7q4o by Molmil](/molmil-images/mine/7q4o) | Substrate-bound A-like U2 snRNP | Descriptor: | BPS oligo, PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, ... | Authors: | Tholen, J, Galej, W.P. | Deposit date: | 2021-11-01 | Release date: | 2022-03-30 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
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2PEH
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![BU of 2peh by Molmil](/molmil-images/mine/2peh) | Crystal structure of the UHM domain of human SPF45 in complex with SF3b155-ULM5 | Descriptor: | Splicing factor 3B subunit 1, Splicing factor 45 | Authors: | Corsini, L, Basquin, J, Hothorn, M, Sattler, M. | Deposit date: | 2007-04-03 | Release date: | 2007-06-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Nat.Struct.Mol.Biol., 14, 2007
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7Q4P
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![BU of 7q4p by Molmil](/molmil-images/mine/7q4p) | U2 snRNP after ATP-dependent remodelling | Descriptor: | PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, Splicing factor 3A subunit 3, ... | Authors: | Tholen, J, Galej, W.P. | Deposit date: | 2021-11-01 | Release date: | 2022-03-30 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.15 Å) | Cite: | Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
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7Q3L
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![BU of 7q3l by Molmil](/molmil-images/mine/7q3l) | Human 17S U2 snRNP 5' domain | Descriptor: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ... | Authors: | Tholen, J, Galej, W.P. | Deposit date: | 2021-10-28 | Release date: | 2022-03-30 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.21 Å) | Cite: | Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
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3LQV
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![BU of 3lqv by Molmil](/molmil-images/mine/3lqv) | Branch Recognition by SF3b14 | Descriptor: | ADENINE, Pre-mRNA branch site protein p14, Splicing factor 3B subunit 1 | Authors: | Schellenberg, M.J, MacMillan, A.M. | Deposit date: | 2010-02-10 | Release date: | 2011-01-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Branch Recognition by SF3b14 Rna, 17, 2011
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7B9C
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7EVO
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![BU of 7evo by Molmil](/molmil-images/mine/7evo) | The cryo-EM structure of the human 17S U2 snRNP | Descriptor: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, RNA helicase, ... | Authors: | Zhang, X, Zhan, X, Shi, Y. | Deposit date: | 2021-05-21 | Release date: | 2022-08-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural insights into branch site proofreading by human spliceosome. Nat.Struct.Mol.Biol., 2024
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2F9D
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![BU of 2f9d by Molmil](/molmil-images/mine/2f9d) | 2.5 angstrom resolution structure of the spliceosomal protein p14 bound to region of SF3b155 | Descriptor: | Pre-mRNA branch site protein p14, Splicing factor 3B subunit 1 | Authors: | Schellenberg, M.J, Edwards, R.A, Ritchie, D.B, Glover, J.N.M, Macmillan, A.M. | Deposit date: | 2005-12-05 | Release date: | 2006-01-24 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of a core spliceosomal protein interface Proc.Natl.Acad.Sci.Usa, 103, 2006
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7EVN
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![BU of 7evn by Molmil](/molmil-images/mine/7evn) | The cryo-EM structure of the DDX42-SF3b complex | Descriptor: | ATP-dependent RNA helicase DDX42, PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, ... | Authors: | Zhang, X, Zhan, X, Shi, Y. | Deposit date: | 2021-05-21 | Release date: | 2022-08-03 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural insights into branch site proofreading by human spliceosome Nat.Struct.Mol.Biol., 2024
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8H6L
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![BU of 8h6l by Molmil](/molmil-images/mine/8h6l) | Cryo-EM structure of human exon-defined spliceosome in the early B state. | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | Deposit date: | 2022-10-18 | Release date: | 2024-05-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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8HK1
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![BU of 8hk1 by Molmil](/molmil-images/mine/8hk1) | The cryo-EM structure of human pre-17S U2 snRNP | Descriptor: | ATP-dependent RNA helicase DDX42, HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, ... | Authors: | Zhang, X, Zhan, X, Shi, Y. | Deposit date: | 2022-11-24 | Release date: | 2023-03-08 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly. Nat Commun, 14, 2023
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8H6K
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![BU of 8h6k by Molmil](/molmil-images/mine/8h6k) | Cryo-EM structure of human exon-defined spliceosome in the mature B state. | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | Deposit date: | 2022-10-18 | Release date: | 2024-05-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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7DVQ
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![BU of 7dvq by Molmil](/molmil-images/mine/7dvq) | Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'-O-[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine, Armadillo repeat-containing protein 7, ... | Authors: | Bai, R, Wan, R, Wang, L, Xu, K, Zhang, Q, Lei, J, Shi, Y. | Deposit date: | 2021-01-14 | Release date: | 2021-03-31 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structure of the activated human minor spliceosome. Science, 371, 2021
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7B0I
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![BU of 7b0i by Molmil](/molmil-images/mine/7b0i) | Structure of a minimal SF3B core in complex with spliceostatin A (form II) | Descriptor: | PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3,Splicing factor 3B subunit 3,Splicing factor 3B subunit 3, ... | Authors: | Cretu, C, Pena, V. | Deposit date: | 2020-11-19 | Release date: | 2021-08-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
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7OMF
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![BU of 7omf by Molmil](/molmil-images/mine/7omf) | Structure of a minimal SF3B core in complex with sudemycin D6 (form I) | Descriptor: | PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ... | Authors: | Cretu, C, Pena, V. | Deposit date: | 2021-05-21 | Release date: | 2021-08-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
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2F9J
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7B92
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7B91
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![BU of 7b91 by Molmil](/molmil-images/mine/7b91) | |
7VPX
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![BU of 7vpx by Molmil](/molmil-images/mine/7vpx) | The cryo-EM structure of the human pre-A complex | Descriptor: | 5SS, DnaJ homolog subfamily C member 8, PHD finger-like domain-containing protein 5A, ... | Authors: | Zhang, X, Zhan, X, Shi, Y. | Deposit date: | 2021-10-18 | Release date: | 2023-05-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into branch site proofreading by human spliceosome. Nat.Struct.Mol.Biol., 2024
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6EN4
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![BU of 6en4 by Molmil](/molmil-images/mine/6en4) | SF3b core in complex with a splicing modulator | Descriptor: | PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ... | Authors: | Cretu, C, Pena, V. | Deposit date: | 2017-10-04 | Release date: | 2018-06-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.08 Å) | Cite: | Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds. Mol. Cell, 70, 2018
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7OPI
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![BU of 7opi by Molmil](/molmil-images/mine/7opi) | |