7B0I

Structure of a minimal SF3B core in complex with spliceostatin A (form II)

Summary for 7B0I

• Entry DOI: 10.2210/pdb7b0i/pdb
• Related: 5IFE 6EN4
• Descriptor: Splicing factor 3B subunit 3,Splicing factor 3B subunit 3,Splicing factor 3B subunit 3, Splicing factor 3B subunit 5, Splicing factor 3B subunit 1, ... (7 entities in total)
• Functional Keywords: sf3b, pre-mrna splicing, splicing modulator, spliceostatin a, splicing
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 219877.62

Authors

Cretu, C.,Pena, V. (deposition date: 2020-11-19, release date: 2021-08-04, Last modification date: 2024-01-31)

• Primary citation: Cretu, C.,Gee, P.,Liu, X.,Agrawal, A.,Nguyen, T.V.,Ghosh, A.K.,Cook, A.,Jurica, M.,Larsen, N.A.,Pena, V.; Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors.; Nat Commun, 12:4491-4491, 2021; PubMed: 34301950; DOI: 10.1038/s41467-021-24741-1

Experimental method

X-RAY DIFFRACTION (3 Å)