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PDB: 15 results

5NQZ
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BU of 5nqz by Molmil
Structure of a fHbp(V1.1):PorA(P1.16) chimera. Fusion at fHbp position 309.
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Factor H binding protein,Major outer membrane protein P.IA,Factor H binding protein, ...
Authors:Johnson, S, Hollingshead, S, Lea, S.M, Tang, C.M.
Deposit date:2017-04-21
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
7LCV
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BU of 7lcv by Molmil
Factor H enhancing human antibody fragment (Fab) to meningococcal Factor H binding protein
Descriptor: CHLORIDE ION, Factor H binding protein, Immunoglobulin heavy chain Fd fragment, ...
Authors:Beernink, P.T, Sands, N.
Deposit date:2021-01-11
Release date:2021-06-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site.
Plos Pathog., 17, 2021
2YPV
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BU of 2ypv by Molmil
Crystal structure of the Meningococcal vaccine antigen factor H binding protein in complex with a bactericidal antibody
Descriptor: 1,2-ETHANEDIOL, FAB 12C1, LIPOPROTEIN
Authors:Malito, E, Veggi, D, Bottomley, M.J.
Deposit date:2012-11-01
Release date:2013-02-20
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Defining a Protective Epitope on Factor H Binding Protein, a Key Meningococcal Virulence Factor and Vaccine Antigen.
Proc.Natl.Acad.Sci.USA, 110, 2013
2Y7S
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BU of 2y7s by Molmil
Structure of a designed meningococcal antigen (factor H binding protein, mutant G1) inducing broad protective immunity
Descriptor: FACTOR H BINDING PROTEIN
Authors:Malito, E, Spraggon, G, Bottomley, M.J.
Deposit date:2011-02-01
Release date:2011-07-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rational Design of a Meningococcal Antigen Inducing Broad Protective Immunity.
Sci.Transl.Med, 3, 2011
7KET
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BU of 7ket by Molmil
Factor H enhancing human antibody fragment (Fab) to meningococcal Factor H binding protein
Descriptor: Factor H binding protein, Immunoglobulin gamma, heavy chain Fd fragment, ...
Authors:Beernink, P.T, Sands, N.
Deposit date:2020-10-12
Release date:2021-06-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site.
Plos Pathog., 17, 2021
5O14
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BU of 5o14 by Molmil
Co-crystal structure of a cross-reactive bactericidal human antibody targeting meningococcal vaccine antigen factor H binding protein
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Fab 1A12 Heavy Chain, ...
Authors:Lopez-Sagaseta, J.
Deposit date:2017-05-18
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.195 Å)
Cite:Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp.
Nat Commun, 9, 2018
2W81
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Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H
Descriptor: COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN
Authors:Schneider, M.C, Prosser, B.E, Caesar, J.J.E, Kugelberg, E, Li, S, Zhang, Q, Quoraishi, S, Lovett, J.E, Deane, J.E, Sim, R.B, Roversi, P, Johnson, S, Tang, C.M, Lea, S.M.
Deposit date:2009-01-08
Release date:2009-03-03
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Neisseria Meningitidis Recruits Factor H Using Protein Mimicry of Host Carbohydrates.
Nature, 458, 2009
2W80
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BU of 2w80 by Molmil
Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H
Descriptor: COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN
Authors:Schneider, M.C, Prosser, B.E, Caesar, J.J.E, Kugelberg, E, Li, S, Zhang, Q, Quoraishi, S, Lovett, J.E, Deane, J.E, Sim, R.B, Roversi, P, Johnson, S, Tang, C.M, Lea, S.M.
Deposit date:2009-01-08
Release date:2009-03-03
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Neisseria Meningitidis Recruits Factor H Using Protein Mimicry of Host Carbohydrates.
Nature, 458, 2009
6XZW
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BU of 6xzw by Molmil
Crystal structure of the meningococcal vaccine antigen fHbp in complex with a cross-reactive human Fab.
Descriptor: 1,2-ETHANEDIOL, Fab 4B3 (heavy chain), Fab 4B3 (light chain), ...
Authors:Veggi, D, Cozzi, R.
Deposit date:2020-02-05
Release date:2020-10-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp.
Plos Pathog., 16, 2020
4AYD
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BU of 4ayd by Molmil
Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 R106A mutant
Descriptor: 1,2-ETHANEDIOL, COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN
Authors:Johnson, S, Tan, L, van der Veen, S, Caesar, J, Goicoechea De Jorge, E, Everett, R.J, Bai, X, Exley, R.M, Ward, P.N, Ruivo, N, Trivedi, K, Cumber, E, Jones, R, Newham, L, Staunton, D, Borrow, R, Pickering, M, Lea, S.M, Tang, C.M.
Deposit date:2012-06-20
Release date:2012-11-07
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules
Plos Pathog., 8, 2012
4AYE
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BU of 4aye by Molmil
Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 E283AE304A mutant
Descriptor: 1,2-ETHANEDIOL, COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN
Authors:Johnson, S, Tan, L, van der Veen, S, Caesar, J, Goicoechea De Jorge, E, Everett, R.J, Bai, X, Exley, R.M, Ward, P.N, Ruivo, N, Trivedi, K, Cumber, E, Jones, R, Newham, L, Staunton, D, Borrow, R, Pickering, M, Lea, S.M, Tang, C.M.
Deposit date:2012-06-20
Release date:2012-11-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
7SBZ
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BU of 7sbz by Molmil
JAR5 Fab bound to fHbp v1.1 crystallized in space group I422
Descriptor: CADMIUM ION, Factor H-binding protein, JAR5 Heavy Chain, ...
Authors:Chesterman, C, Malito, E, Bottomley, M.J.
Deposit date:2021-09-26
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Active Learning for Rapid Design: An iterative AI approach for accelerated vaccine design that combines active machine learning and high-throughput experimental evaluation
To Be Published
5T5F
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BU of 5t5f by Molmil
Neisseria meningitidis factor H binding protein in complex with monoclonal antibody JAR5
Descriptor: Factor H binding protein variant B24, Monoclonal antibody Jar5 heavy chain, Monoclonal antibody Jar5 light chain
Authors:Malito, E.
Deposit date:2016-08-30
Release date:2016-11-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Neisseria meningitidis factor H-binding protein bound to monoclonal antibody JAR5: implications for antibody synergy.
Biochem. J., 473, 2016
5NQX
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BU of 5nqx by Molmil
Structure of a fHbp(V1.1):PorA(P1.16) chimera. Fusion at fHbp position 294.
Descriptor: Factor H binding protein,Major outer membrane protein P.IA,Factor H binding protein
Authors:Johnson, S, Jongerius, I, Lea, S.M, Tang, C.M.
Deposit date:2017-04-21
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.66 Å)
Cite:Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
1YS5
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BU of 1ys5 by Molmil
Solution structure of the antigenic domain of GNA1870 of Neisseria meningitidis
Descriptor: lipoprotein
Authors:Cantini, F, Savino, S, Masignani, V, Pizza, M, Scarselli, M, Swennen, E, Romagnoli, G, Veggi, D, Banci, L, Rappuoli, R.
Deposit date:2005-02-07
Release date:2006-02-07
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis
J.Biol.Chem., 281, 2006

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