6XZW

Crystal structure of the meningococcal vaccine antigen fHbp in complex with a cross-reactive human Fab.

Summary for 6XZW

• Entry DOI: 10.2210/pdb6xzw/pdb
• Descriptor: Lipoprot_C domain-containing protein, Fab 4B3 (light chain), Fab 4B3 (heavy chain), ... (5 entities in total)
• Functional Keywords: antigen-antibody complex, epitope mapping, lipoprotein, neisseria meningitidis, immune system
• Biological source: Neisseria meningitidis serogroup B (strain MC58); More
• Total number of polymer chains: 3
• Total formula weight: 74512.36

Authors

Veggi, D.,Cozzi, R. (deposition date: 2020-02-05, release date: 2020-10-14, Last modification date: 2024-01-24)

• Primary citation: Veggi, D.,Bianchi, F.,Santini, L.,Lo Surdo, P.,Chesterman, C.C.,Pansegrau, W.,Bechi, N.,Huang, Y.,Masignani, V.,Pizza, M.,Rappuoli, R.,Bottomley, M.J.,Cozzi, R.,Maione, D.; 4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp.; Plos Pathog., 16:e1008882-e1008882, 2020; PubMed: 33007046; DOI: 10.1371/journal.ppat.1008882

Experimental method

X-RAY DIFFRACTION (2.4 Å)