2W81
Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H
Summary for 2W81
Entry DOI | 10.2210/pdb2w81/pdb |
Related | 1FHC 1HAQ 1HFH 1KOV 2G7I 2JGW 2JGX 2UWN 2V8E 2W80 |
Descriptor | COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN (3 entities in total) |
Functional Keywords | glycoprotein, immune evasion, age-related macular degeneration, innate immunity, immune response, disease mutation, factor h, complement alternate pathway, vaccine candidate, immune system |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Secreted: P08603 |
Total number of polymer chains | 6 |
Total formula weight | 123615.31 |
Authors | Schneider, M.C.,Prosser, B.E.,Caesar, J.J.E.,Kugelberg, E.,Li, S.,Zhang, Q.,Quoraishi, S.,Lovett, J.E.,Deane, J.E.,Sim, R.B.,Roversi, P.,Johnson, S.,Tang, C.M.,Lea, S.M. (deposition date: 2009-01-08, release date: 2009-03-03, Last modification date: 2023-12-13) |
Primary citation | Schneider, M.C.,Prosser, B.E.,Caesar, J.J.E.,Kugelberg, E.,Li, S.,Zhang, Q.,Quoraishi, S.,Lovett, J.E.,Deane, J.E.,Sim, R.B.,Roversi, P.,Johnson, S.,Tang, C.M.,Lea, S.M. Neisseria Meningitidis Recruits Factor H Using Protein Mimicry of Host Carbohydrates. Nature, 458:890-, 2009 Cited by PubMed: 19225461DOI: 10.1038/NATURE07769 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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