2JGX
Structure of CCP module 7 of complement factor H - The AMD Not at risk varient (402Y)
Summary for 2JGX
| Entry DOI | 10.2210/pdb2jgx/pdb |
| Related | 1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2JGW |
| NMR Information | BMRB: 7421 |
| Descriptor | COMPLEMENT FACTOR H (1 entity in total) |
| Functional Keywords | age related macular degeneration, age-related macular degeneration, disease mutation, glycosaminoglycan, alternative splicing, complement alternate pathway, glycoprotein, innate immunity, immune response, sushi, factor h, complement, polymorphism |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Secreted: P08603 |
| Total number of polymer chains | 1 |
| Total formula weight | 7010.09 |
| Authors | Herbert, A.P.,Deakin, J.A.,Schmidt, C.Q.,Blaum, B.S.,Egan, C.,Ferreira, V.P.,Pangburn, M.K.,Lyon, M.,Uhrin, D.,Barlow, P.N. (deposition date: 2007-02-16, release date: 2007-03-20, Last modification date: 2018-05-02) |
| Primary citation | Herbert, A.P.,Deakin, J.A.,Schmidt, C.Q.,Blaum, B.S.,Egan, C.,Ferreira, V.P.,Pangburn, M.K.,Lyon, M.,Uhrin, D.,Barlow, P.N. Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism. J. Biol. Chem., 282:18960-18968, 2007 Cited by PubMed: 17360715DOI: 10.1074/jbc.M609636200 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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