PDB: 504 resultsInfo pagesStatus searchChemie searchBIRD

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6NF4	Structure of zebrafish Otop1 in nanodiscs Descriptor: CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, Otopetrin1 Authors: Saotome, K, Lee, W.H, Liman, E.R, Ward, A.B. Deposit date: 2018-12-18 Release date: 2019-06-05 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.98 Å) Cite: Structures of the otopetrin proton channels Otop1 and Otop3. Nat.Struct.Mol.Biol., 26, 2019
6Z01	DNA Topoisomerase Descriptor: CHLORIDE ION, DNA topoisomerase I Authors: Takahashi, T.S, Gadelle, D, Forterre, P, Mayer, C, Petrella, S. Deposit date: 2020-05-07 Release date: 2021-11-17 Last modified: 2023-05-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states. Nat Commun, 13, 2022
6Z03	DNA Topoisomerase Descriptor: DNA topoisomerase I Authors: Takahashi, T.S, Gadelle, D, Forterre, P, Mayer, C, Petrella, S. Deposit date: 2020-05-07 Release date: 2021-11-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states. Nat Commun, 13, 2022
6NF6	Structure of chicken Otop3 in nanodiscs Descriptor: CHOLESTEROL HEMISUCCINATE, Otopetrin3 Authors: Saotome, K, Lee, W.H, Liman, E.R, Ward, A.B. Deposit date: 2018-12-18 Release date: 2019-06-05 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.32 Å) Cite: Structures of the otopetrin proton channels Otop1 and Otop3. Nat.Struct.Mol.Biol., 26, 2019
8CZQ	The crystal structure of MtbTOP1 in complex with both G- and T-segments Descriptor: ACETATE ION, DNA (5'-D(*CP*TP*TP*CP*CP*GP*CP*TP*TP*GP*AP*C)-3'), DNA topoisomerase 1, ... Authors: Tan, K, Tse-Dinh, Y.-C. Deposit date: 2022-05-25 Release date: 2022-12-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.78 Å) Cite: The interaction between transport-segment DNA and topoisomerase IA-crystal structure of MtbTOP1 in complex with both G- and T-segments. Nucleic Acids Res., 51, 2023
1SC7	Human DNA Topoisomerase I (70 Kda) In Complex With The Indenoisoquinoline MJ-II-38 and Covalent Complex With A 22 Base Pair DNA Duplex Descriptor: 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... Authors: Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. Deposit date: 2004-02-11 Release date: 2005-04-19 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005
1SEU	Human DNA Topoisomerase I (70 Kda) In Complex With The Indolocarbazole SA315F and Covalent Complex With A 22 Base Pair DNA Duplex Descriptor: 2,10-DIHYDROXY-12-(BETA-D-GLUCOPYRANOSYL)-6,7,12,13-TETRAHYDROINDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... Authors: Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. Deposit date: 2004-02-18 Release date: 2005-04-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3 Å) Cite: Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005
1T8I	Human DNA Topoisomerase I (70 Kda) In Complex With The Poison Camptothecin and Covalent Complex With A 22 Base Pair DNA Duplex Descriptor: 4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZO[B,H]FLUORENE-3,13-DIONE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... Authors: Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. Deposit date: 2004-05-12 Release date: 2005-05-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3 Å) Cite: Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005
5D5H	Crystal structure of Mycobacterium tuberculosis Topoisomerase I Descriptor: ACETATE ION, DNA topoisomerase 1, GLYCEROL, ... Authors: Tan, K, Cheng, B, Tse-Dinh, Y.C. Deposit date: 2015-08-10 Release date: 2015-12-16 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Insights from the Structure of Mycobacterium tuberculosis Topoisomerase I with a Novel Protein Fold. J.Mol.Biol., 428, 2016
3IGC	Smallpox virus topoisomerase-DNA transition state Descriptor: 5'-D(*AP*TP*TP*CP*C)-3', 5'-D(*CP*GP*GP*AP*AP*TP*AP*AP*GP*GP*GP*CP*GP*AP*CP*A)-3', 5'-D(*GP*TP*GP*TP*CP*GP*CP*CP*CP*TP*T)-3', ... Authors: Perry, K, Hwang, Y, Bushman, F.D, Van Duyne, G.D. Deposit date: 2009-07-27 Release date: 2010-03-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Insights from the Structure of a Smallpox Virus Topoisomerase-DNA Transition State Mimic. Structure, 18, 2010
1NH3	Human Topoisomerase I Ara-C Complex Descriptor: 5'-D(*(GNG)P*GP*AP*AP*AP*AP*AP*UP*UP*UP*UP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*UP*(UBB))-3', 5'-D(*AP*AP*AP*AP*AP*TP*UP*UP*UP*UP*CP*(CAR)P*AP*AP*GP*UP*CP*UP*UP*UP*UP*T)-3', ... Authors: Chrencik, J.E, Burgin, A.B, Pommier, Y, Stewart, L, Redinbo, M.R. Deposit date: 2002-12-18 Release date: 2003-03-04 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural Impact of the Leukemia Drug 1-beta-D-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex J.Biol.Chem., 278, 2003
1OIS	YEAST DNA TOPOISOMERASE I, N-TERMINAL FRAGMENT Descriptor: DNA TOPOISOMERASE I Authors: Lue, N, Sharma, A, Mondragon, A, Wang, J.C. Deposit date: 1996-09-14 Release date: 1997-03-12 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A 26 kDa yeast DNA topoisomerase I fragment: crystallographic structure and mechanistic implications. Structure, 3, 1995
2H7G	Structure of variola topoisomerase non-covalently bound to DNA Descriptor: 5'-D(*TP*AP*AP*TP*AP*AP*GP*GP*GP*CP*GP*AP*CP*A)-3', 5'-D(*TP*TP*GP*TP*CP*GP*CP*CP*CP*TP*TP*A)-3', DNA topoisomerase 1 Authors: Perry, K, Hwang, Y, Bushman, F.D, Van Duyne, G.D. Deposit date: 2006-06-02 Release date: 2006-08-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for specificity in the poxvirus topoisomerase. Mol.Cell, 23, 2006
2H7F	Structure of variola topoisomerase covalently bound to DNA Descriptor: 5'-D(*TP*AP*AP*TP*AP*AP*GP*GP*GP*CP*GP*AP*CP*A)-3', 5'-D(*TP*TP*GP*TP*CP*GP*CP*CP*CP*TP*T)-3', DNA topoisomerase 1 Authors: Perry, K, Hwang, Y, Bushman, F.D, Van Duyne, G.D. Deposit date: 2006-06-02 Release date: 2006-08-15 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural basis for specificity in the poxvirus topoisomerase. Mol.Cell, 23, 2006
6PCM	Crystal Structure of Mycobacterium smegmatis Topoisomerase I with ssDNA bound to both N- and C-terminal domains Descriptor: DNA (5'-D(P*AP*GP*TP*GP*AP*GP*CP*GP*AP*GP*CP*TP*TP*CP*CP*GP*CP*TP*TP*GP*AP*CP*TP*T)-3'), DNA topoisomerase 1, SULFATE ION Authors: Tan, K, Cao, N, Tse-Dinh, Y.C. Deposit date: 2019-06-17 Release date: 2020-03-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.107 Å) Cite: Mechanistic insights from structure of Mycobacterium smegmatis topoisomerase I with ssDNA bound to both N- and C-terminal domains. Nucleic Acids Res., 48, 2020
1ECL	AMINO TERMINAL 67KDA DOMAIN OF ESCHERICHIA COLI DNA TOPOISOMERASE I (RESIDUES 2-590 OF MATURE PROTEIN) CLONING ARTIFACT ADDS TWO RESIDUES TO THE AMINO-TERMINUS WHICH WERE NOT OBSERVED IN THE EXPERIMENTAL ELECTRON DENSITY (GLY-2, SER-1). Descriptor: ESCHERICHIA COLI TOPOISOMERASE I Authors: Lima, C.D, Wang, J.C, Mondragon, A. Deposit date: 1995-05-05 Release date: 1995-07-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I. Nature, 367, 1994
1EJ9	CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX Descriptor: DNA (5'-D(*C*AP*AP*AP*AP*AP*GP*AP*CP*TP*CP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'), DNA (5'-D(*C*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*GP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), DNA TOPOISOMERASE I Authors: Redinbo, M.R, Champoux, J.J, Hol, W.G. Deposit date: 2000-03-01 Release date: 2000-08-03 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA. Biochemistry, 39, 2000
1MW9	Crystal Structure of H365R mutant of 67 kDA N-terminal fragment of E. coli DNA Topoisomerase I Descriptor: DNA Topoisomerase I, SULFATE ION Authors: Perry, K, Mondragon, A. Deposit date: 2002-09-27 Release date: 2003-10-14 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Structure of a Complex between E. coli DNA Topoisomerase I and Single-Stranded DNA. Structure, 11, 2003
1MW8	Crystal Structure of a Complex between H365R mutant of 67 kDA N-terminal fragment of E. coli DNA Topoisomerase I and 5'-ACTTCGGGATG-3' Descriptor: 5'-D(*AP*CP*TP*TP*CP*GP*GP*GP*AP*TP*G)-3', DNA Topoisomerase I, SULFATE ION, ... Authors: Perry, K, Mondragon, A. Deposit date: 2002-09-27 Release date: 2003-10-14 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of a Complex between E. coli DNA Topoisomerase I and Single-Stranded DNA. Structure, 11, 2003
2GAJ	Structure of Full Length Topoisomerase I from Thermotoga maritima in monoclinic crystal form Descriptor: DNA topoisomerase I Authors: Hansen, G. Deposit date: 2006-03-09 Release date: 2006-04-25 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of Full Length Topoisomerase I from Thermotoga maritima J.Mol.Biol., 358, 2006
2GAI	Structure of Full Length Topoisomerase I from Thermotoga maritima in triclinic crystal form Descriptor: DNA topoisomerase I Authors: Hansen, G. Deposit date: 2006-03-08 Release date: 2006-04-25 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal Structure of Full Length Topoisomerase I from Thermotoga maritima J.Mol.Biol., 358, 2006
3PWT	Crystal structure of mutant E.coli topoisomerase IA Descriptor: DNA topoisomerase, SULFATE ION Authors: Zhang, Z, Bokun, C, Tse-Dinh, Y.-C. Deposit date: 2010-12-08 Release date: 2010-12-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of mutant E.coli topoisomerase IA To be Published
1R49	Human topoisomerase I (Topo70) double mutant K532R/Y723F Descriptor: 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I Authors: Interthal, H, Quigley, P.M, Hol, W.G, Champoux, J.J. Deposit date: 2003-10-03 Release date: 2003-12-16 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.13 Å) Cite: The role of lysine 532 in the catalytic mechanism of human topoisomerase I. J.Biol.Chem., 279, 2004
1RRJ	Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I Descriptor: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... Authors: Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R. Deposit date: 2003-12-08 Release date: 2004-07-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Mechanisms of camptothecin resistance by human topoisomerase I mutations J.Mol.Biol., 339, 2004
1RR8	Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I Descriptor: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... Authors: Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R. Deposit date: 2003-12-08 Release date: 2004-07-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Mechanisms of camptothecin resistance by human topoisomerase I mutations J.Mol.Biol., 339, 2004

 

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