1R49
Human topoisomerase I (Topo70) double mutant K532R/Y723F
Summary for 1R49
Entry DOI | 10.2210/pdb1r49/pdb |
Related | 1A36 1EJ9 1K4S 1K4T 1LPQ 1TMC |
Descriptor | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I, ... (4 entities in total) |
Functional Keywords | protein, dna, topoisomerase i, isomerase-dna complex, isomerase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleolus: P11387 |
Total number of polymer chains | 3 |
Total formula weight | 83675.90 |
Authors | Interthal, H.,Quigley, P.M.,Hol, W.G.,Champoux, J.J. (deposition date: 2003-10-03, release date: 2003-12-16, Last modification date: 2024-02-14) |
Primary citation | Interthal, H.,Quigley, P.M.,Hol, W.G.,Champoux, J.J. The role of lysine 532 in the catalytic mechanism of human topoisomerase I. J.Biol.Chem., 279:2984-2992, 2004 Cited by PubMed: 14594810DOI: 10.1074/jbc.M309959200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.13 Å) |
Structure validation
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