1R49
Human topoisomerase I (Topo70) double mutant K532R/Y723F
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3' | polymer | 22 | 6790.5 | 1 | |||
| 2 | C | 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3' | polymer | 22 | 6705.4 | 1 | |||
| 3 | A | DNA topoisomerase I | polymer | 592 | 70180.1 | 1 | UniProt (P11387) Pfam (PF02919) Pfam (PF01028) Pfam (PF14370) In PDB | Homo sapiens (human) | |
| 4 | water | water | 18.0 | 29 | Chemie (HOH) |
Sequence modifications
A: 174 - 765 (UniProt: P11387)
| PDB | External Database | Details |
|---|---|---|
| Arg 532 | Lys 532 | engineered mutation |
| Phe 723 | Tyr 723 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 83675.9 | |
| All* | Total formula weight | 83675.9 |
