1RR8

Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I

Summary for 1RR8

• Entry DOI: 10.2210/pdb1rr8/pdb
• Descriptor: 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I, ... (6 entities in total)
• Functional Keywords: protein-dna complex, topotecan, camptothecin, nucleic acid, human topoisomerase i, isomerase-dna complex, isomerase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleolus: P11387
• Total number of polymer chains: 3
• Total formula weight: 81144.59

Authors

Chrencik, J.E.,Staker, B.L.,Burgin, A.B.,Stewart, L.,Redinbo, M.R. (deposition date: 2003-12-08, release date: 2004-07-06, Last modification date: 2023-11-15)

• Primary citation: Chrencik, J.E.,Staker, B.L.,Burgin, A.B.,Pourquier, P.,Pommier, Y.,Stewart, L.,Redinbo, M.R.; Mechanisms of camptothecin resistance by human topoisomerase I mutations; J.Mol.Biol., 339:773-784, 2004; PubMed: 15165849; DOI: 10.1016/j.jmb.2004.03.077

Experimental method

X-RAY DIFFRACTION (2.6 Å)