1RR8
Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I
Functional Information from GO Data
Functional Information from PDB Data
| site_id | 1 |
| Number of Residues | |
| Details |
| Chain | Residue |
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE TTG A 1991 |
| Chain | Residue |
| A | DT10 |
| C | LYS532 |
| C | ASP533 |
| C | THR718 |
| C | ASN722 |
| A | DG11 |
| A | DG12 |
| A | TTC100 |
| A | HOH886 |
| B | DC112 |
| B | DA113 |
| C | GLU356 |
| C | ARG364 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TTC A 100 |
| Chain | Residue |
| A | DT10 |
| A | DG11 |
| A | DG12 |
| A | HOH886 |
| A | TTG1991 |
| B | DC112 |
| B | DA113 |
| B | HOH878 |
| C | GLU356 |
| C | ARG364 |
| C | LYS532 |
| C | ASP533 |
| C | THR718 |
| C | PTR723 |
Functional Information from PROSITE/UniProt
| site_id | PS00176 |
| Number of Residues | 19 |
| Details | TOPO_IB_1 Topoisomerase (Topo) IB-type active site signature. EnkqialGTSKlnYLdprI |
| Chain | Residue | Details |
| C | GLU710-ILE728 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Region: {"description":"Interaction with DNA"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"O-(3'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01382","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10130","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10841763","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12426403","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12533542","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15165849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15801827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16033260","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9488644","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Site: {"description":"Interaction with DNA"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by CK2","evidences":[{"source":"PubMed","id":"23185622","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1k4t |
| Chain | Residue | Details |
| C | HIS632 | |
| C | ARG488 | |
| C | ARG590 |
