1RR8
Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3' | polymer | 22 | 6806.5 | 1 | |||
| 2 | B (B) | 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3' | polymer | 22 | 6690.4 | 1 | |||
| 3 | C (C) | DNA topoisomerase I | polymer | 565 | 66786.9 | 1 | UniProt (P11387) Pfam (PF02919) Pfam (PF01028) Pfam (PF14370) | Homo sapiens (human) | |
| 4 | D (A) | 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID | non-polymer | 439.5 | 1 | Chemie (TTG) | |||
| 5 | E (A) | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE | non-polymer | 421.4 | 1 | Chemie (TTC) | |||
| 6 | F, G, H (A, B, C) | water | water | 18.0 | 304 | Chemie (HOH) |
Sequence modifications
C: 203 - 765 (UniProt: P11387)
| PDB | External Database | Details |
|---|---|---|
| Ala 201 | - | cloning artifact |
| Ala 202 | - | cloning artifact |
| Ser 361 | Phe 361 | engineered mutation |
| Gln 634 | Arg 634 | engineered mutation |
| Ptr 723 | Tyr 723 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 80283.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 860.9 | |
| All* | Total formula weight | 81144.6 |
