6PCM

Crystal Structure of Mycobacterium smegmatis Topoisomerase I with ssDNA bound to both N- and C-terminal domains

Summary for 6PCM

• Entry DOI: 10.2210/pdb6pcm/pdb
• Descriptor: DNA topoisomerase 1, DNA (5'-D(P*AP*GP*TP*GP*AP*GP*CP*GP*AP*GP*CP*TP*TP*CP*CP*GP*CP*TP*TP*GP*AP*CP*TP*T)-3'), SULFATE ION (3 entities in total)
• Functional Keywords: topoisomerase i, ss dna binding, n-terminal domain, c-terminal domain, isomerase-dna complex, isomerase/dna
• Biological source: Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155); More
• Total number of polymer chains: 4
• Total formula weight: 202624.23

Authors

Tan, K.,Cao, N.,Tse-Dinh, Y.C. (deposition date: 2019-06-17, release date: 2020-03-25, Last modification date: 2023-10-11)

• Primary citation: Cao, N.,Tan, K.,Zuo, X.,Annamalai, T.,Tse-Dinh, Y.C.; Mechanistic insights from structure of Mycobacterium smegmatis topoisomerase I with ssDNA bound to both N- and C-terminal domains.; Nucleic Acids Res., 48:4448-4462, 2020; PubMed: 32232337; DOI: 10.1093/nar/gkaa201

Experimental method

X-RAY DIFFRACTION (3.107 Å)