1OIS

YEAST DNA TOPOISOMERASE I, N-TERMINAL FRAGMENT

Summary for 1OIS

Entry DOI	10.2210/pdb1ois/pdb
Descriptor	DNA TOPOISOMERASE I (2 entities in total)
Functional Keywords	isomerase, topoisomerase, dna-binding protein, dna binding protein
Biological source	Saccharomyces cerevisiae (baker's yeast)
Cellular location	Nucleus, nucleolus: P04786
Total number of polymer chains	1
Total formula weight	26085.76
Authors	Lue, N.,Sharma, A.,Mondragon, A.,Wang, J.C. (deposition date: 1996-09-14, release date: 1997-03-12, Last modification date: 2024-02-14)
Primary citation	Lue, N.,Sharma, A.,Mondragon, A.,Wang, J.C. A 26 kDa yeast DNA topoisomerase I fragment: crystallographic structure and mechanistic implications. Structure, 3:1315-1322, 1995 Cited by PubMed Abstract: Type I DNA topoisomerases, divided mechanistically into two subfamilies, are ubiquitous enzymes that participate in replication and transcription. In addition to its role in these fundamental processes, the biological importance of eukaryotic DNA topoisomerase I is underscored by its identification as the target of the antitumor alkaloid camptothecin. An understanding of the mechanism of catalysis and interactions with camptothecin and other drugs has been hampered by a lack of detailed structural information. PubMed: 8747458 DOI: 10.1016/S0969-2126(01)00269-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation