6PRW
 
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6TZV
 | | Crystal Structure of the carboxyltransferase subunit of ACC (AccD6) in complex with inhibitor Phenyl-Cyclodiaone from Mycobacterium tuberculosis | | Descriptor: | 4'-[(6-chloro-1,3-benzothiazol-2-yl)oxy]-6-hydroxy-4,4-dimethyl-4,5-dihydro[1,1'-biphenyl]-2(3H)-one, Probable propionyl-CoA carboxylase beta chain 6 | | Authors: | Reddy, M.C.M, Zhou, N, Sacchettini, J, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2019-08-13 | | Release date: | 2020-08-19 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.388 Å) | | Cite: | Novel herbicidal derivatives that inhibit carboxyltransferase subunit of the acetyl-CoA carboxylase in Mycobacterium tuberculosis
To Be Published
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4L6W
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4ASI
 | | Crystal structure of human ACACA C-terminal domain | | Descriptor: | ACETYL-COA CARBOXYLASE 1 | | Authors: | Froese, D.S, Muniz, J.R.C, Kiyani, W, Krojer, T, Vollmar, M, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U, Yue, W.W. | | Deposit date: | 2012-05-01 | | Release date: | 2012-08-29 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal Structure of Human Acaca C-Terminal Domain
To be Published
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3PGQ
 | | Crystal Structure of the Carboxyltransferase Domain of S. cerevisiae Acetyl CoA Carboxylase in Complex with Pinoxaden | | Descriptor: | 8-(2-ethenyl-6-ethyl-4-methylphenyl)tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepine-7,9(8H)-dione, Acetyl-CoA carboxylase | | Authors: | Tong, L, Yu, L.P.C, Kim, Y.S. | | Deposit date: | 2010-11-02 | | Release date: | 2010-12-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden.
Proc.Natl.Acad.Sci.USA, 107, 2010
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1OD2
 | | Acetyl-CoA Carboxylase Carboxyltransferase Domain | | Descriptor: | ACETYL COENZYME *A, ACETYL-COENZYME A CARBOXYLASE, ADENINE | | Authors: | Zhang, H, Yang, Z, Shen, Y, Tong, L. | | Deposit date: | 2003-02-12 | | Release date: | 2003-04-03 | | Last modified: | 2018-06-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase.
Science, 299, 2003
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4Q0G
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4WZ8
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4WYO
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6PK2
 | | CRYSTAL STRUCTURE OF THE CARBOXYLTRANSFERASE SUBUNIT OF ACC (ACCD6) IN COMPLEX WITH INHIBITOR QUIZALOFOP-P derivative FROM MYCOBACTERIUM TUBERCULOSIS | | Descriptor: | 2-{4-[(6-fluoro-1,3-benzothiazol-2-yl)oxy]-2-hydroxyphenyl}-N-methylacetamide, Propionyl-CoA carboxylase subunit beta | | Authors: | Reddy, M.C.M, Nian, Z, Michele, T.C.B, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2019-06-28 | | Release date: | 2020-07-01 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.402 Å) | | Cite: | Elucidating the Inhibition and specificity of binding of
herbicidal aryloxyphenoxypropionates derivatives to Mycobacterium tuberculosis carboxyltransferase
domain of acetyl-coenzyme A(AccD6).
To Be Published
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6P7U
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7W5U
 | | Acetyl-CoA Carboxylase-AccB | | Descriptor: | Acetyl-CoA carboxylase complex, beta-chain, GLYCEROL, ... | | Authors: | Ali, I, Zheng, J. | | Deposit date: | 2021-11-30 | | Release date: | 2022-04-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Crystal structure of Acetyl-CoA carboxylase (AccB) from Streptomyces antibioticus and insights into the substrate-binding through in silico mutagenesis and biophysical investigations.
Comput Biol Med, 145, 2022
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4G2R
 | | Crystal Structure of the carboxyltransferase subunit of ACC (AccD6) in complex with inhibitor haloxyfop from Mycobacterium tuberculosis | | Descriptor: | (2R)-2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid, AccD6, Carboxyltransferase beta-subunit of Acyl-CoA Carboxylase | | Authors: | Reddy, M.C.M, Bruning, J.B, Thurman, C, Sherekar, M, Valluru, S, Ehrenfeld, H, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2012-07-12 | | Release date: | 2014-02-19 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Structure, Activity, and Inhibition of the Carboxyltransferase beta-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis.
Antimicrob.Agents Chemother., 58, 2014
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4FB8
 | | Crystal Structure of apo Acyl-CoA Carboxylase | | Descriptor: | Probable propionyl-CoA carboxylase beta chain 6 | | Authors: | Reddy, M.C.M, Bruning, J.B, Sherekar, M, Valluru, S, Ehrenfeld, H, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2012-05-22 | | Release date: | 2014-02-19 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure, Activity, and Inhibition of the Carboxyltransferase beta-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis.
Antimicrob.Agents Chemother., 58, 2014
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2BZR
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1PIX
 | | Crystal structure of the carboxyltransferase subunit of the bacterial ion pump glutaconyl-coenzyme A decarboxylase | | Descriptor: | FORMIC ACID, Glutaconyl-CoA decarboxylase A subunit, SULFATE ION | | Authors: | Wendt, K.S, Schall, I, Huber, R, Buckel, W, Jacob, U. | | Deposit date: | 2003-05-30 | | Release date: | 2003-08-05 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of the carboxyltransferase subunit of the bacterial sodium ion pump glutaconyl-coenzyme A decarboxylase
Embo J., 22, 2003
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1OD4
 | | Acetyl-CoA Carboxylase Carboxyltransferase Domain | | Descriptor: | ACETYL-COENZYME A CARBOXYLASE, ADENINE | | Authors: | Zhang, H, Yang, Z, Shen, Y, Tong, L. | | Deposit date: | 2003-02-12 | | Release date: | 2003-04-03 | | Last modified: | 2018-06-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase.
Science, 299, 2003
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1ON9
 | | Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core (with hydrolyzed methylmalonyl-coenzyme a bound) | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CADMIUM ION, METHYLMALONYL-COENZYME A, ... | | Authors: | Hall, P.R, Wang, Y.-F, Rivera-Hainaj, R.E, Zheng, X, Pustai-Carey, M, Carey, P.R, Yee, V.C. | | Deposit date: | 2003-02-27 | | Release date: | 2003-05-20 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core
Embo J., 22, 2003
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1ON3
 | | Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core (with methylmalonyl-coenzyme a and methylmalonic acid bound) | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CADMIUM ION, METHYLMALONIC ACID, ... | | Authors: | Hall, P.R, Wang, Y.-F, Rivera-Hainaj, R.E, Zheng, X, Pustai-Carey, M, Carey, P.R, Yee, V.C. | | Deposit date: | 2003-02-26 | | Release date: | 2003-05-20 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core
Embo J., 22, 2003
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1XNY
 | | Biotin and propionyl-CoA bound to Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB) | | Descriptor: | BIOTIN, propionyl Coenzyme A, propionyl-CoA carboxylase complex B subunit | | Authors: | Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C. | | Deposit date: | 2004-10-05 | | Release date: | 2004-11-09 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
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3IB9
 | | Propionyl-CoA Carboxylase Beta Subunit, D422L | | Descriptor: | BIOTIN, Propionyl-CoA carboxylase complex B subunit, SULFATE ION | | Authors: | Diacovich, L, Arabolaza, A, Shillito, E.M, Lin, T.-W, Mitchell, D.L, Pham, H, Melgar, M.M. | | Deposit date: | 2009-07-15 | | Release date: | 2010-06-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor.
Biochemistry, 49, 2010
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2A7S
 | | Crystal Structure of the Acyl-CoA Carboxylase, AccD5, from Mycobacterium tuberculosis | | Descriptor: | Probable propionyl-CoA carboxylase beta chain 5 | | Authors: | Lin, T, Melgar, M, Purdon, J, Tseng, T, Tsai, S.C. | | Deposit date: | 2005-07-06 | | Release date: | 2006-02-21 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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3K8X
 | | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with tepraloxydim | | Descriptor: | (5S)-2-[(1E)-N-{[(2E)-3-chloroprop-2-en-1-yl]oxy}propanimidoyl]-3-hydroxy-5-(tetrahydro-2H-pyran-4-yl)cyclohex-2-en-1-one, Acetyl-CoA carboxylase | | Authors: | Xiang, S, Callaghan, M.M, Watson, K.G, Tong, L. | | Deposit date: | 2009-10-15 | | Release date: | 2009-12-01 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim.
Proc.Natl.Acad.Sci.USA, 106, 2009
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1XNV
 | | Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #1 | | Descriptor: | propionyl-CoA carboxylase complex B subunit | | Authors: | Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C. | | Deposit date: | 2004-10-05 | | Release date: | 2004-11-09 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
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1XO6
 | | Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #3 | | Descriptor: | propionyl-CoA carboxylase complex B subunit | | Authors: | Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C. | | Deposit date: | 2004-10-05 | | Release date: | 2004-11-09 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
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