4G2R

Crystal Structure of the carboxyltransferase subunit of ACC (AccD6) in complex with inhibitor haloxyfop from Mycobacterium tuberculosis

Summary for 4G2R

• Entry DOI: 10.2210/pdb4g2r/pdb
• Related: 4FB8
• Descriptor: AccD6, Carboxyltransferase beta-subunit of Acyl-CoA Carboxylase, (2R)-2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (3 entities in total)
• Functional Keywords: structural genomics, tb structural genomics consortium, tbsgc, crotonase super family, carboxyltransferase, transferase-herbicide complex, transferase, transferase-transferase inhibitor complex, psi-2, protein structure initiative, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 101844.67

Authors

Reddy, M.C.M.,Bruning, J.B.,Thurman, C.,Sherekar, M.,Valluru, S.,Ehrenfeld, H.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2012-07-12, release date: 2014-02-19, Last modification date: 2023-09-13)

• Primary citation: Reddy, M.C.,Breda, A.,Bruning, J.B.,Sherekar, M.,Valluru, S.,Thurman, C.,Ehrenfeld, H.,Sacchettini, J.C.; Structure, Activity, and Inhibition of the Carboxyltransferase beta-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis.; Antimicrob.Agents Chemother., 58:6122-6132, 2014; PubMed: 25092705; DOI: 10.1128/AAC.02574-13

Experimental method

X-RAY DIFFRACTION (2.28 Å)