PDB: 340 resultsInfo pagesStatus searchChemie searchBIRD

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2GH6	Crystal structure of a HDAC-like protein with 9,9,9-trifluoro-8-oxo-N-phenylnonan amide bound Descriptor: 9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE, Histone deacetylase-like amidohydrolase, POTASSIUM ION, ... Authors: Nielsen, T.K, Hildmann, C, Riester, D, Wegener, D, Schwienhorst, A, Ficner, R. Deposit date: 2006-03-26 Release date: 2007-03-20 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.203 Å) Cite: Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor. Acta Crystallogr.,Sect.F, 63, 2007
7JOM	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with TO-317 Descriptor: 1,2-ETHANEDIOL, FORMIC ACID, Hdac6 protein, ... Authors: Watson, P.R, Christianson, D.W. Deposit date: 2020-08-06 Release date: 2021-06-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype. J.Med.Chem., 64, 2021
1ZZ3	Crystal structure of a HDAC-like protein with CypX bound Descriptor: 3-CYCLOPENTYL-N-HYDROXYPROPANAMIDE, Histone deacetylase-like amidohydrolase, POTASSIUM ION, ... Authors: Nielsen, T.K, Hildmann, C, Dickmanns, A, Schwienhorst, A, Ficner, R. Deposit date: 2005-06-13 Release date: 2005-11-29 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Crystal structure of a bacterial class 2 histone deacetylase homologue J.Mol.Biol., 354, 2005
1ZZ1	Crystal structure of a HDAC-like protein with SAHA bound Descriptor: Histone deacetylase-like amidohydrolase, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, POTASSIUM ION, ... Authors: Nielsen, T.K, Hildmann, C, Dickmanns, A, Schwienhorst, A, Ficner, R. Deposit date: 2005-06-13 Release date: 2005-11-29 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Crystal structure of a bacterial class 2 histone deacetylase homologue J.Mol.Biol., 354, 2005
6J6T	Crystal Structure of HDA15 HD domain Descriptor: Histone deacetylase 15, POTASSIUM ION, SULFATE ION, ... Authors: Cheng, Y.S, Hsu, J.C, Hung, H.C, Liu, T.C. Deposit date: 2019-01-15 Release date: 2020-01-22 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Structure of Arabidopsis HISTONE DEACETYLASE15. Plant Physiol., 184, 2020
6MR5	Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with a mercaptoacetamide-based inhibitor Descriptor: 1,2-ETHANEDIOL, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... Authors: Porter, N.J, Christianson, D.W. Deposit date: 2018-10-11 Release date: 2018-12-05 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor. ACS Med Chem Lett, 9, 2018
3ZNR	HDAC7 bound with inhibitor TMP269 Descriptor: HISTONE DEACETYLASE 7, N-{[4-(4-phenyl-1,3-thiazol-2-yl)tetrahydro-2H-pyran-4-yl]methyl}-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide, POTASSIUM ION, ... Authors: Lobera, m, madauss, k, pohlhaus, d, trump, r, nolan, m. Deposit date: 2013-02-15 Release date: 2013-03-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Selective Class Iia Histone Deacetylase Inhibition Via a Non-Chelating Zinc Binding Group Nat.Chem.Biol., 9, 2013
3ZNS	HDAC7 bound with TFMO inhibitor tmp942 Descriptor: HISTONE DEACETYLASE 7, N-{[1-methyl-4-(4-phenyl-1,3-thiazol-2-yl)piperidin-4-yl]methyl}-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide, POTASSIUM ION, ... Authors: Lobera, M, Madauss, K.P, Pohlhaus, D.T, Trump, R.P, Nolan, M.A. Deposit date: 2013-02-15 Release date: 2013-03-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Selective Class Iia Histone Deacetylase Inhibition Via a Non-Chelating Zinc Binding Group Nat.Chem.Biol., 9, 2013
4RN2	Crystal structure of S39D HDAC8 in complex with a largazole analogue. Descriptor: (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3-thia-7,10,14,17,21-pentaazatricyclo[14.3.1.1~2,5~]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione, Histone deacetylase 8, POTASSIUM ION, ... Authors: Decroos, C, Christianson, D.W. Deposit date: 2014-10-22 Release date: 2015-04-08 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8. Biochemistry, 54, 2015
4RN1	Crystal structure of S39D HDAC8 in complex with a largazole analogue. Descriptor: (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3-thia-7,10,14,20,21-pentaazatricyclo[14.3.1.1~2,5~]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione, GLYCEROL, Histone deacetylase 8, ... Authors: Decroos, C, Christianson, D.W. Deposit date: 2014-10-22 Release date: 2015-04-08 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8. Biochemistry, 54, 2015
4RN0	Crystal structure of S39D HDAC8 in complex with a largazole analogue. Descriptor: (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3,17-dithia-7,10,14,19,20-pentaazatricyclo[14.2.1.1~2,5~]icosa-1(18),2(20),16(19)-triene-6,9,13-trione, GLYCEROL, Histone deacetylase 8, ... Authors: Decroos, C, Christianson, D.W. Deposit date: 2014-10-22 Release date: 2015-04-08 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.761 Å) Cite: Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8. Biochemistry, 54, 2015
1VKG	Crystal Structure of Human HDAC8 complexed with CRA-19156 Descriptor: 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE, Histone deacetylase 8, SODIUM ION, ... Authors: Somoza, J.R, Skene, R.J, Katz, B.A, Mol, C, Ho, J.D, Jennings, A.J, Luong, C, Arvai, A, Buggy, J.J, Chi, E, Tang, J, Sang, B.-C, Verner, E, Wynands, R, Leahy, E.M, Dougan, D.R, Snell, G, Navre, M, Knuth, M.W, Swanson, R.V, McRee, D.E, Tari, L.W. Deposit date: 2004-05-13 Release date: 2004-07-27 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases Structure, 12, 2004
1C3P	CRYSTAL STRUCTURE OF AN HDAC HOMOLOG FROM AQUIFEX AEOLICUS Descriptor: PROTEIN (HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)) Authors: Finnin, M.S, Donigian, J.R, Pavletich, N.P. Deposit date: 1999-07-28 Release date: 1999-09-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature, 401, 1999
1C3S	CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH SAHA Descriptor: HDLP (HISTONE DEACETYLASE-LIKE PROTEIN), OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ZINC ION Authors: Finnin, M.S, Donigian, J.R, Pavletich, N.P. Deposit date: 1999-07-28 Release date: 1999-09-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature, 401, 1999
1W22	Crystal structure of inhibited human HDAC8 Descriptor: HISTONE DEACETYLASE 8, N-HYDROXY-4-(METHYL{[5-(2-PYRIDINYL)-2-THIENYL]SULFONYL}AMINO)BENZAMIDE, POTASSIUM ION, ... Authors: Vannini, A, Volpari, C, Caroli Casavola, E, Di Marco, S. Deposit date: 2004-06-25 Release date: 2004-09-24 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal Structure of a Eukaryotic Zn-Dependent Histone Deacetylase,Human Hdac8,Complexed with a Hydroxamic Acid Inhibitor Proc.Natl.Acad.Sci.USA, 101, 2004
1C3R	CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH TRICHOSTATIN A Descriptor: HDLP (HISTONE DEACETYLASE-LIKE PROTEIN), TRICHOSTATIN A, ZINC ION Authors: Finnin, M.S, Donigian, J.R, Pavletich, N.P. Deposit date: 1999-07-28 Release date: 1999-09-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature, 401, 1999
1T69	Crystal Structure of human HDAC8 complexed with SAHA Descriptor: Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ZINC ION Authors: Somoza, J.R, Skene, R.J, Katz, B.A, Mol, C, Ho, J.D, Jennings, A.J, Luong, C, Arvai, A, Buggy, J.J, Chi, E, Tang, J, Sang, B.-C, Verner, E, Wynands, R, Leahy, E.M, Dougan, D.R, Snell, G, Navre, M, Knuth, M.W, Swanson, R.V, McRee, D.E, Tari, L.W. Deposit date: 2004-05-05 Release date: 2004-07-27 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.91 Å) Cite: Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases Structure, 12, 2004
3MAX	Crystal Structure of Human HDAC2 complexed with an N-(2-aminophenyl)benzamide Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, Histone deacetylase 2, ... Authors: Skene, R.J, Jennings, A.J. Deposit date: 2010-03-24 Release date: 2010-04-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg.Med.Chem.Lett., 20, 2010
1T67	Crystal Structure of Human HDAC8 complexed with MS-344 Descriptor: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Histone deacetylase 8, SODIUM ION, ... Authors: Somoza, J.R, Skene, R.J, Katz, B.A, Mol, C, Ho, J.D, Jennings, A.J, Luong, C, Arvai, A, Buggy, J.J, Chi, E, Tang, J, Sang, B.-C, Verner, E, Wynands, R, Leahy, E.M, Dougan, D.R, Snell, G, Navre, M, Knuth, M.W, Swanson, R.V, McRee, D.E, Tari, L.W. Deposit date: 2004-05-05 Release date: 2004-07-27 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases Structure, 12, 2004
3MEN	Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak Descriptor: Acetylpolyamine aminohydrolase, IODIDE ION, POTASSIUM ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2010-03-31 Release date: 2010-04-21 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.2 Å) Cite: SAD phasing using iodide ions in a high-throughput structural genomics environment. J Struct Funct Genomics, 12, 2011
2V5W	Crystal structure of HDAC8-substrate complex Descriptor: GLYCYL-GLYCYL-GLYCINE, HISTONE DEACETYLASE 8, PEPTIDIC SUBSTRATE, ... Authors: Di Marco, S, Vannini, A, Volpari, C. Deposit date: 2007-07-10 Release date: 2007-09-04 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex Embo Rep., 8, 2007
2VCG	Crystal structure of a HDAC-like protein HDAH from Bordetella sp. with the bound inhibitor ST-17 Descriptor: CHLORIDE ION, GLYCEROL, HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE, ... Authors: Dickmanns, A, Strasser, A, Ficner, R. Deposit date: 2007-09-24 Release date: 2008-01-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Phenylalanine-Containing Hydroxamic Acids as Selective Inhibitors of Class Iib Histone Deacetylases (Hdacs). Bioorg.Med.Chem., 16, 2008
1T64	Crystal Structure of human HDAC8 complexed with Trichostatin A Descriptor: CALCIUM ION, Histone deacetylase 8, SODIUM ION, ... Authors: Somoza, J.R, Skene, R.J, Katz, B.A, Mol, C, Ho, J.D, Jennings, A.J, Luong, C, Arvai, A, Buggy, J.J, Chi, E, Tang, J, Sang, B.-C, Verner, E, Wynands, R, Leahy, E.M, Dougan, D.R, Snell, G, Navre, M, Knuth, M.W, Swanson, R.V, McRee, D.E, Tari, L.W. Deposit date: 2004-05-05 Release date: 2004-07-27 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases Structure, 12, 2004
2V5X	Crystal structure of HDAC8-inhibitor complex Descriptor: (2R)-N~8~-HYDROXY-2-{[(5-METHOXY-2-METHYL-1H-INDOL-3-YL)ACETYL]AMINO}-N~1~-[2-(2-PHENYL-1H-INDOL-3-YL)ETHYL]OCTANEDIAMIDE, HISTONE DEACETYLASE 8, POTASSIUM ION, ... Authors: Di Marco, S, Vannini, A, Volpari, C, Gallinari, P, Jones, P, Mattu, M, Carfi, A, Defrancesco, R, Steinkuhler, C. Deposit date: 2007-07-10 Release date: 2007-09-04 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex Embo Rep., 8, 2007
3MZ6	Crystal structure of D101L Fe2+ HDAC8 complexed with M344 Descriptor: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, FE (II) ION, Histone deacetylase 8, ... Authors: Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W. Deposit date: 2010-05-11 Release date: 2010-06-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49, 2010

 

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