7JOM
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with TO-317
Summary for 7JOM
Entry DOI | 10.2210/pdb7jom/pdb |
Descriptor | Hdac6 protein, N-hydroxy-4-({[(pyridin-3-yl)methyl][(2,3,4,5-tetrafluorophenyl)sulfonyl]amino}methyl)benzamide, 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | hydrolase, histone deacetylase, inhibitor, metallohydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 2 |
Total formula weight | 82206.40 |
Authors | Watson, P.R.,Christianson, D.W. (deposition date: 2020-08-06, release date: 2021-06-16, Last modification date: 2023-10-18) |
Primary citation | Olaoye, O.O.,Watson, P.R.,Nawar, N.,Geletu, M.,Sedighi, A.,Bukhari, S.,Raouf, Y.S.,Manaswiyoungkul, P.,Erdogan, F.,Abdeldayem, A.,Cabral, A.D.,Hassan, M.M.,Toutah, K.,Shouksmith, A.E.,Gawel, J.M.,Israelian, J.,Radu, T.B.,Kachhiyapatel, N.,de Araujo, E.D.,Christianson, D.W.,Gunning, P.T. Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype. J.Med.Chem., 64:2691-2704, 2021 Cited by PubMed: 33576627DOI: 10.1021/acs.jmedchem.0c01922 PDB entries with the same primary citation |
Experimental method |
Structure validation
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