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6MR5

Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with a mercaptoacetamide-based inhibitor

Summary for 6MR5
Entry DOI10.2210/pdb6mr5/pdb
DescriptorHdac6 protein, ZINC ION, POTASSIUM ION, ... (8 entities in total)
Functional Keywordshistone deacetylase, zinc hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceDanio rerio (Zebrafish)
Total number of polymer chains2
Total formula weight82012.16
Authors
Porter, N.J.,Christianson, D.W. (deposition date: 2018-10-11, release date: 2018-12-05, Last modification date: 2024-03-13)
Primary citationPorter, N.J.,Shen, S.,Barinka, C.,Kozikowski, A.P.,Christianson, D.W.
Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor.
ACS Med Chem Lett, 9:1301-1305, 2018
Cited by
PubMed: 30613344
DOI: 10.1021/acsmedchemlett.8b00487
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

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