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6MR5

Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with a mercaptoacetamide-based inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0004407molecular_functionhistone deacetylase activity
A0006325biological_processchromatin organization
A0016575biological_processhistone deacetylation
B0000118cellular_componenthistone deacetylase complex
B0004407molecular_functionhistone deacetylase activity
B0006325biological_processchromatin organization
B0016575biological_processhistone deacetylation
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 801
ChainResidue
AASP612
AHIS614
AASP705
AW45804

site_idAC2
Number of Residues5
Detailsbinding site for residue K A 802
ChainResidue
AASP610
AASP612
AHIS614
ASER633
ALEU634

site_idAC3
Number of Residues6
Detailsbinding site for residue K A 803
ChainResidue
APHE623
AASP626
AVAL629
ATYR662
AHOH952
AHOH973

site_idAC4
Number of Residues16
Detailsbinding site for residue W45 A 804
ChainResidue
APRO464
ASER531
AHIS573
AHIS574
AGLY582
APHE583
AASP612
AHIS614
APHE643
AGLY743
ATYR745
AZN801
AHOH982
BARG636
BGLU638
BALA641

site_idAC5
Number of Residues10
Detailsbinding site for residue PEG A 805
ChainResidue
AHIS615
AASN617
AHIS621
ATYR637
APHE642
APRO644
AASN645
ASER646
AASP648
AALA649

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN B 801
ChainResidue
BASP612
BHIS614
BASP705
BW45804

site_idAC7
Number of Residues5
Detailsbinding site for residue K B 802
ChainResidue
BASP610
BASP612
BHIS614
BSER633
BLEU634

site_idAC8
Number of Residues6
Detailsbinding site for residue K B 803
ChainResidue
BPHE623
BASP626
BVAL629
BTYR662
BHOH931
BHOH1000

site_idAC9
Number of Residues15
Detailsbinding site for residue W45 B 804
ChainResidue
AASP460
AHIS462
AHOH1007
BHIS463
BSER531
BHIS573
BHIS574
BGLY582
BPHE583
BASP612
BHIS614
BPHE643
BGLY743
BTYR745
BZN801

site_idAD1
Number of Residues6
Detailsbinding site for residue FLC B 805
ChainResidue
BARG472
BASN746
BTHR748
BHOH913
BHOH929
BHOH1026

site_idAD2
Number of Residues5
Detailsbinding site for residue PEG B 806
ChainResidue
BASP449
BGLN450
BPHE474
BARG488
BHOH1048

site_idAD3
Number of Residues4
Detailsbinding site for residue EDO B 807
ChainResidue
AHIS683
BHIS684
BSER796
BHOH1033

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PDB entries from 2024-11-13

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