PDB: 46006 resultsInfo pagesStatus searchChemie searchBIRD

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6U18	Directed evolution of a biosensor selective for the macrolide antibiotic clarithromycin Descriptor: CITRATE ANION, CLARITHROMYCIN, Erythromycin resistance repressor protein Authors: Li, Y, Reed, M, Wright, H.T, Cropp, T.A, Williams, G. Deposit date: 2019-08-15 Release date: 2020-08-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Development of Genetically Encoded Biosensors for Reporting the Methyltransferase-Dependent Biosynthesis of Semisynthetic Macrolide Antibiotics. Acs Synth Biol, 2021
6XOG	Structure of SUMO1-ML786519 adduct bound to SAE Descriptor: SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... Authors: Sintchak, M, Lane, W, Bump, N. Deposit date: 2020-07-07 Release date: 2021-03-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
6XOH	Structure of SUMO1-ML00789344 adduct bound to SAE Descriptor: SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... Authors: Sintchak, M, Lane, W, Bump, N. Deposit date: 2020-07-07 Release date: 2021-03-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.226 Å) Cite: Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
6XOI	Structure of SUMO1-ML00752641 adduct bound to SAE Descriptor: SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... Authors: Sintchak, M, Lane, W, Bump, N. Deposit date: 2020-07-07 Release date: 2021-03-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
8A92	p53-Y220C Core Domain in Complex with a Bromo-trifluoro-pyrazole-amine Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-bromanyl-5-(trifluoromethyl)-1H-pyrazol-3-amine, Cellular tumor antigen p53, ... Authors: Stahlecker, J, Braun, M.B, Stehle, T, Boeckler, F.M. Deposit date: 2022-06-27 Release date: 2022-11-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C. Rsc Med Chem, 13, 2022
3BBX	The Hsp15 protein fitted into the low resolution Cryo-EM map of the 50S.nc-tRNA.Hsp15 complex Descriptor: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... Authors: Jiang, L, Abrahams, J.P. Deposit date: 2007-11-11 Release date: 2008-10-21 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (10 Å) Cite: Recycling of Aborted Ribosomal 50S Subunit-Nascent Chain-tRNA Complexes by the Heat Shock Protein Hsp15. J.Mol.Biol., 386, 2009
7AHO	RUVBL1-RUVBL2 heterohexameric ring after binding of RNA helicase DHX34 Descriptor: ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 Authors: Lopez-Perrote, A, Rodriguez, C.F, Llorca, O. Deposit date: 2020-09-25 Release date: 2020-11-25 Method: ELECTRON MICROSCOPY (4.18 Å) Cite: Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM. Elife, 9, 2020
5MZL	Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and fragment like molekule N-quinolin-5-ylpyridine-3-carboxamide Descriptor: GLYCEROL, Pimtide, Serine/threonine-protein kinase pim-1, ... Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-01 Release date: 2018-02-14 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.955 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5N4O	Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and fragment like molekule (E)-3-(p-tolyl)acrylic acid Descriptor: (~{E})-3-(4-methylphenyl)prop-2-enoic acid, Pimtide, Serine/threonine-protein kinase pim-1 Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-11 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.22 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5N4U	Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and fragment like molekule 5-(2-amino-1,3-thiazol-4-yl)-1,3-dihydrobenzimidazol-2-one Descriptor: 5-(2-azanyl-1,3-thiazol-4-yl)-1,3-dihydrobenzimidazol-2-one, Pimtide, Serine/threonine-protein kinase pim-1 Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-11 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.202 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5N5M	Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and (R)-3-(2-((isoquinolin-5-ylmethyl)(methyl)carbamoyl)phenyl)pyrrolidin-1-ium Descriptor: Pimtide, Serine/threonine-protein kinase pim-1, ~{N}-(isoquinolin-5-ylmethyl)-~{N}-methyl-2-[(3~{R})-pyrrolidin-3-yl]benzamide Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-14 Release date: 2018-03-07 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.21 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5N52	Crystal structure of human Pim-1 kinase in complex with a consensus peptide and fragment like molecule (E)-3-(2,3-dimethoxyphenyl)acrylic acid Descriptor: (~{E})-3-(2,3-dimethoxyphenyl)prop-2-enoic acid, Pimtide, Serine/threonine-protein kinase pim-1 Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-11 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.252 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5N50	Crystal structure of human Pim-1 kinase in complex with a consensus peptide and fragment like molecule 2-(4-chlorophenyl)sulfanylacetohydrazide Descriptor: 2-(4-chlorophenyl)sulfanylethanehydrazide, Pimtide, Serine/threonine-protein kinase pim-1 Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-11 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.92 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5N4N	Crystal structure of human Pim-1 kinase in complex with a consensus peptide and fragment like molecule 3,4-dimethyl-5-(1H-1,2,4-triazol-3-yl)thiophene-2-carbonitrile Descriptor: 3,4-dimethyl-5-(1~{H}-1,2,4-triazol-3-yl)thiophene-2-carbonitrile, Pimtide, Serine/threonine-protein kinase pim-1 Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-11 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.09 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5N4X	Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and fragment like molekule 4,5-dibromothiophene-2-carbohydrazide Descriptor: 4,5-bis(bromanyl)thiophene-2-carbohydrazide, Pimtide, Serine/threonine-protein kinase pim-1 Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-11 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5N4V	Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and fragment like molekule 2-cyclopropyl-4,5-dimethylthieno[5,4-d]pyrimidine-6-carboxylic acid Descriptor: 2-cyclopropyl-4,5-dimethyl-thieno[2,3-d]pyrimidine-6-carboxylic acid, GLYCEROL, Pimtide, ... Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-11 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.85 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5N4Y	Crystal structure of human Pim-1 kinase in complex with a consensus peptide and fragment like molecule 2,5-dihydro-1H-isothiochromeno[3,4-d]pyrazol-3-one Descriptor: 2,5-dihydro-1~{H}-isothiochromeno[4,3-c]pyrazol-3-one, Pimtide, Serine/threonine-protein kinase pim-1 Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-11 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.56 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5N5L	Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and [2-oxo-2-(1H-pyrrol-2-yl)ethyl] 5-bromo-1H-indole-3-carboxylate Descriptor: 5-bromanyl-1~{H}-indole-3-carboxylic acid, GLYCEROL, Pimtide, ... Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-14 Release date: 2018-03-07 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.97 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5NDT	Crystal structure of human Pim-1 kinase in complex with a consensus peptide and fragment like molecule (E)-3-(2-(thiophen-2-yl)vinyl)-3,4-dihydroquinoxalin-2(1H)-one Descriptor: 3-(2-thiophen-2-ylethenyl)-1~{H}-quinoxalin-2-one, GLYCEROL, Pimtide, ... Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-03-09 Release date: 2018-05-16 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.985 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5N4R	Crystal structure of human Pim-1 kinase in complex with a consensus peptide and fragment like molecule 2-(azepan-1-yl)-1-(1H-indol-3-yl)propan-1-one Descriptor: 2-(azepan-1-yl)-1-(1~{H}-indol-3-yl)propan-1-one, GLYCEROL, Pimtide, ... Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-11 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.13 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5N4Z	Crystal structure of human Pim-1 kinase in complex with a consensus peptide and fragment like molecule (E)-4-(4-hydroxyphenyl)but-3-en-2-one Descriptor: (~{E})-4-(4-hydroxyphenyl)but-3-en-2-one, Pimtide, Serine/threonine-protein kinase pim-1 Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-11 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.257 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
1ZT9	E. coli trp repressor, tetragonal crystal form Descriptor: SULFATE ION, TRYPTOPHAN, Trp operon repressor Authors: Lawson, C.L, Chin, A.S, Benoff, B, Yung, B.H. Deposit date: 2005-05-26 Release date: 2006-05-09 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2 Å) Cite: Two association modes for E. coli trp repressor dimer-dimer interactions To be Published
5N51	Crystal structure of human Pim-1 kinase in complex with a consensus peptide and fragment like molecule 3,4-Dibromothiophene-2-carboxylic acid Descriptor: 3,4-bis(bromanyl)thiophene-2-carboxylic acid, Pimtide, Serine/threonine-protein kinase pim-1 Authors: Siefker, C, Heine, A, Klebe, G. Deposit date: 2017-02-11 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.118 Å) Cite: A crystallographic fragment study with human Pim-1 kinase to be published
5O12	Crystal structure of PIM1 kinase in complex with small-molecule inhibitor Descriptor: (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, IMIDAZOLE, Serine/threonine-protein kinase pim-1 Authors: Dubin, G, Bogusz, J. Deposit date: 2017-05-17 Release date: 2017-11-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors. Sci Rep, 7, 2017
7LS1	80S ribosome from mouse bound to eEF2 (Class II) Descriptor: 28S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... Authors: Loerch, S, Smith, P.R, Kunder, N, Stanowick, A.D, Lou, T.-F, Campbell, Z.T. Deposit date: 2021-02-17 Release date: 2021-11-03 Last modified: 2021-12-08 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance. Nat Commun, 12, 2021

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