5N5M

Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and (R)-3-(2-((isoquinolin-5-ylmethyl)(methyl)carbamoyl)phenyl)pyrrolidin-1-ium

Summary for 5N5M

• Entry DOI: 10.2210/pdb5n5m/pdb
• Descriptor: Serine/threonine-protein kinase pim-1, Pimtide, ~{N}-(isoquinolin-5-ylmethyl)-~{N}-methyl-2-[(3~{R})-pyrrolidin-3-yl]benzamide, ... (4 entities in total)
• Functional Keywords: serine threonine kinase, transferase, proto-oncogene, fragment, pim-1, consensus peptide
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 37650.87

Authors

Siefker, C.,Heine, A.,Klebe, G. (deposition date: 2017-02-14, release date: 2018-03-07, Last modification date: 2024-01-17)

• Primary citation: Siefker, C.,Heine, A.,Taylor, C.,Kolb, P.,Hardes, K.,Steinmetzer, A.,Klebe, G.; A crystallographic fragment study with human Pim-1 kinase; to be published,

Experimental method

X-RAY DIFFRACTION (2.21 Å)