5N5M
Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and (R)-3-(2-((isoquinolin-5-ylmethyl)(methyl)carbamoyl)phenyl)pyrrolidin-1-ium
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase pim-1 | polymer | 313 | 35712.6 | 1 | UniProt (P11309) Pfam (PF00069) In PDB | Homo sapiens (Human) | |
| 2 | B | Pimtide | polymer | 14 | 1592.8 | 1 | Homo sapiens | ||
| 3 | A | ~{N}-(isoquinolin-5-ylmethyl)-~{N}-methyl-2-[(3~{R})-pyrrolidin-3-yl]benzamide | non-polymer | 345.4 | 1 | Chemie (8O8) | |||
| 4 | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A: 1 - 313 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Gly 250 | Arg 250 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37305.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 345.4 | |
| All* | Total formula weight | 37650.9 |
