6XOG

Structure of SUMO1-ML786519 adduct bound to SAE

Summary for 6XOG

• Entry DOI: 10.2210/pdb6xog/pdb
• Descriptor: SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, Small ubiquitin-related modifier 1, ... (7 entities in total)
• Functional Keywords: sae, sumo1, covalent inhibitor, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 122165.26

Authors

Sintchak, M.,Lane, W.,Bump, N. (deposition date: 2020-07-07, release date: 2021-03-10, Last modification date: 2023-10-18)

• Primary citation: Langston, S.P.,Grossman, S.,England, D.,Afroze, R.,Bence, N.,Bowman, D.,Bump, N.,Chau, R.,Chuang, B.C.,Claiborne, C.,Cohen, L.,Connolly, K.,Duffey, M.,Durvasula, N.,Freeze, S.,Gallery, M.,Galvin, K.,Gaulin, J.,Gershman, R.,Greenspan, P.,Grieves, J.,Guo, J.,Gulavita, N.,Hailu, S.,He, X.,Hoar, K.,Hu, Y.,Hu, Z.,Ito, M.,Kim, M.S.,Lane, S.W.,Lok, D.,Lublinsky, A.,Mallender, W.,McIntyre, C.,Minissale, J.,Mizutani, H.,Mizutani, M.,Molchinova, N.,Ono, K.,Patil, A.,Qian, M.,Riceberg, J.,Shindi, V.,Sintchak, M.D.,Song, K.,Soucy, T.,Wang, Y.,Xu, H.,Yang, X.,Zawadzka, A.,Zhang, J.,Pulukuri, S.M.; Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.; J.Med.Chem., 64:2501-2520, 2021; PubMed: 33631934; DOI: 10.1021/acs.jmedchem.0c01491

Experimental method

X-RAY DIFFRACTION (1.98 Å)