5O12
Crystal structure of PIM1 kinase in complex with small-molecule inhibitor
Summary for 5O12
| Entry DOI | 10.2210/pdb5o12/pdb |
| Descriptor | Serine/threonine-protein kinase pim-1, (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, IMIDAZOLE, ... (4 entities in total) |
| Functional Keywords | pim1, kinase, ro-3306, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 34954.52 |
| Authors | Dubin, G.,Bogusz, J. (deposition date: 2017-05-17, release date: 2017-11-01, Last modification date: 2024-01-17) |
| Primary citation | Bogusz, J.,Zrubek, K.,Rembacz, K.P.,Grudnik, P.,Golik, P.,Romanowska, M.,Wladyka, B.,Dubin, G. Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors. Sci Rep, 7:13399-13399, 2017 Cited by PubMed: 29042609DOI: 10.1038/s41598-017-13557-z PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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