6U18

Directed evolution of a biosensor selective for the macrolide antibiotic clarithromycin

Summary for 6U18

Entry DOI	10.2210/pdb6u18/pdb
Descriptor	Erythromycin resistance repressor protein, CLARITHROMYCIN, CITRATE ANION, ... (4 entities in total)
Functional Keywords	macrolide, biosensor, dna-binding, dna binding protein-antibiotic complex, dna binding protein/antibiotic
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	44888.96
Authors	Li, Y.,Reed, M.,Wright, H.T.,Cropp, T.A.,Williams, G. (deposition date: 2019-08-15, release date: 2020-08-19, Last modification date: 2023-10-11)
Primary citation	Li, Y.,Reed, M.,Wright, H.T.,Cropp, T.A.,Williams, G.J. Development of Genetically Encoded Biosensors for Reporting the Methyltransferase-Dependent Biosynthesis of Semisynthetic Macrolide Antibiotics. Acs Synth Biol, 2021 Cited by PubMed: 34546703 DOI: 10.1021/acssynbio.1c00151 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation