6U18
Directed evolution of a biosensor selective for the macrolide antibiotic clarithromycin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0016740 | molecular_function | transferase activity |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue CTY A 201 |
| Chain | Residue |
| A | GLY62 |
| A | HOH324 |
| A | VAL66 |
| A | ASN102 |
| A | TYR103 |
| A | SER106 |
| A | THR122 |
| A | VAL126 |
| A | HOH321 |
| A | HOH322 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue FLC A 202 |
| Chain | Residue |
| A | THR29 |
| A | LEU30 |
| A | SER31 |
| A | ARG41 |
| A | ARG51 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue CTY B 201 |
| Chain | Residue |
| B | THR17 |
| B | GLN65 |
| B | VAL66 |
| B | TYR69 |
| B | LEU89 |
| B | SER92 |
| B | MET93 |
| B | ASN102 |
| B | TYR103 |
| B | VAL126 |
| B | ILE150 |
| B | THR151 |
| B | THR154 |
| B | HOH312 |
| B | HOH322 |
| B | HOH323 |
| B | HOH348 |
