7QP6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qp6 by Molmil](/molmil-images/mine/7qp6) | Structure of the human 48S initiation complex in open state (h48S AUG open) | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Yi, S.-H, Petrychenko, V, Schliep, J.E, Goyal, A, Linden, A, Chari, A, Urlaub, H, Stark, H, Rodnina, M.V, Adio, S, Fischer, N. | Deposit date: | 2022-01-03 | Release date: | 2022-05-11 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Res., 50, 2022
|
|
7QP7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qp7 by Molmil](/molmil-images/mine/7qp7) | Structure of the human 48S initiation complex in closed state (h48S AUG closed) | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Yi, S.-H, Petrychenko, V, Schliep, J.E, Goyal, A, Linden, A, Chari, A, Urlaub, H, Stark, H, Rodnina, M.V, Adio, S, Fischer, N. | Deposit date: | 2022-01-03 | Release date: | 2022-05-11 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Res., 50, 2022
|
|
8JCH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jch by Molmil](/molmil-images/mine/8jch) | |
6EXN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6exn by Molmil](/molmil-images/mine/6exn) | Post-catalytic P complex spliceosome with 3' splice site docked | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Intron lariat: UBC4 RNA, ... | Authors: | Wilkinson, M.E, Fica, S.M, Galej, W.P, Norman, C.M, Newman, A.J, Nagai, K. | Deposit date: | 2017-11-08 | Release date: | 2018-01-17 | Last modified: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection. Science, 358, 2017
|
|
8OEU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8oeu by Molmil](/molmil-images/mine/8oeu) | Structure of the mammalian Pol II-SPT6 complex (composite structure, Structure 4) | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Chen, Y, Kokic, G, Dienemann, C, Dybkov, O, Urlaub, H, Cramer, P. | Deposit date: | 2023-03-13 | Release date: | 2023-10-18 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Structure of the transcribing RNA polymerase II-Elongin complex. Nat.Struct.Mol.Biol., 30, 2023
|
|
8OEW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8oew by Molmil](/molmil-images/mine/8oew) | Structure of the mammalian Pol II-Elongin complex, lacking the ELOA latch (composite structure, structure 2) | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Chen, Y, Kokic, G, Dienemann, C, Dybkov, O, Urlaub, H, Cramer, P. | Deposit date: | 2023-03-13 | Release date: | 2023-10-18 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure of the transcribing RNA polymerase II-Elongin complex. Nat.Struct.Mol.Biol., 30, 2023
|
|
8OF0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8of0 by Molmil](/molmil-images/mine/8of0) | Structure of the mammalian Pol II-SPT6-Elongin complex, Structure 1 | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Chen, Y, Kokic, G, Dienemann, C, Dybkov, O, Urlaub, H, Cramer, P. | Deposit date: | 2023-03-13 | Release date: | 2023-10-18 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Structure of the transcribing RNA polymerase II-Elongin complex. Nat.Struct.Mol.Biol., 30, 2023
|
|
8OEV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8oev by Molmil](/molmil-images/mine/8oev) | Structure of the mammalian Pol II-SPT6-Elongin complex, lacking ELOA latch (composite structure, structure 3) | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Chen, Y, Kokic, G, Dienemann, C, Dybkov, O, Urlaub, H, Cramer, P. | Deposit date: | 2023-03-13 | Release date: | 2023-10-18 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structure of the transcribing RNA polymerase II-Elongin complex. Nat.Struct.Mol.Biol., 30, 2023
|
|
6FLQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6flq by Molmil](/molmil-images/mine/6flq) | |
8K5P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8k5p by Molmil](/molmil-images/mine/8k5p) | |
6FYY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6fyy by Molmil](/molmil-images/mine/6fyy) | Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C2) | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0, 40S ribosomal protein S1, ... | Authors: | Llacer, J.L, Hussain, T, Gordiyenko, Y, Ramakrishnan, V. | Deposit date: | 2018-03-12 | Release date: | 2018-12-05 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition. Elife, 7, 2018
|
|
1Y1W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1y1w by Molmil](/molmil-images/mine/1y1w) | Complete RNA Polymerase II elongation complex | Descriptor: | 5'-D(*AP*AP*GP*TP*AP*CP*T)-3', 5'-D(P*AP*GP*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*TP*GP*GP*TP*CP*AP*T)-3', 5'-R(*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ... | Authors: | Cramer, P, Kettenberger, H, Armache, K.-J. | Deposit date: | 2004-11-19 | Release date: | 2005-01-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS Mol.Cell, 16, 2004
|
|
1Y1V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1y1v by Molmil](/molmil-images/mine/1y1v) | Refined RNA Polymerase II-TFIIS complex | Descriptor: | DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 19 kDa polypeptide, ... | Authors: | Kettenberger, H, Armache, K.-J, Cramer, P. | Deposit date: | 2004-11-19 | Release date: | 2004-12-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS. Mol.Cell, 16, 2004
|
|
6FYX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6fyx by Molmil](/molmil-images/mine/6fyx) | Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C1) | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0, 40S ribosomal protein S1, ... | Authors: | Llacer, J.L, Hussain, T, Gordiyenko, Y, Ramakrishnan, V. | Deposit date: | 2018-03-12 | Release date: | 2018-12-05 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition. Elife, 7, 2018
|
|
1Y1Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1y1y by Molmil](/molmil-images/mine/1y1y) | RNA Polymerase II-TFIIS-DNA/RNA complex | Descriptor: | 5'-D(P*TP*AP*CP*GP*CP*CP*T)-3', 5'-R(P*AP*GP*GP*C)-3', DNA-directed RNA polymerase II 13.6 kDa polypeptide, ... | Authors: | Cramer, P, Kettenberger, H, Armache, K.-J. | Deposit date: | 2004-11-19 | Release date: | 2004-12-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS. Mol.Cell, 16, 2004
|
|
1Y77
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1y77 by Molmil](/molmil-images/mine/1y77) | Complete RNA Polymerase II elongation complex with substrate analogue GMPCPP | Descriptor: | 5'-D(*AP*AP*GP*TP*AP*CP*T)-3', 5'-D(P*AP*GP*TP*AP*CP*TP*TP*AP*CP*T*CP*GP*CP*CP*TP*GP*GP*TP*CP*TP*G)-3', 5'-R(*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ... | Authors: | Kettenberger, H, Armache, K.-J, Cramer, P. | Deposit date: | 2004-12-08 | Release date: | 2005-01-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (4.5 Å) | Cite: | Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS Mol.Cell, 16, 2004
|
|
6GMH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gmh by Molmil](/molmil-images/mine/6gmh) | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 | Descriptor: | CDC73, CTR9,RNA polymerase-associated protein CTR9 homolog,RNA polymerase-associated protein CTR9 homolog, DNA-directed RNA polymerase II subunit RPB9, ... | Authors: | Vos, S.M, Farnung, L, Boehing, M, Linden, A, Wigge, C, Urlaub, H, Cramer, P. | Deposit date: | 2018-05-26 | Release date: | 2018-08-22 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature, 560, 2018
|
|
6GSN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gsn by Molmil](/molmil-images/mine/6gsn) | |
6GOV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gov by Molmil](/molmil-images/mine/6gov) | Structure of THE RNA POLYMERASE LAMBDA-BASED ANTITERMINATION COMPLEX | Descriptor: | 30S ribosomal protein S10, Antitermination protein N, DNA (I), ... | Authors: | Loll, B, Krupp, F, Said, N, Huang, Y, Buerger, J, Mielke, T, Spahn, C.M.T, Wahl, M.C. | Deposit date: | 2018-06-04 | Release date: | 2019-02-13 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor. Mol.Cell, 74, 2019
|
|
6H58
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6h58 by Molmil](/molmil-images/mine/6h58) | Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - Full 100S Hibernating E. coli Ribosome | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ... | Authors: | Beckert, B, Turk, M, Czech, A, Berninghausen, O, Beckmann, R, Ignatova, Z, Plitzko, J, Wilson, D.N. | Deposit date: | 2018-07-24 | Release date: | 2018-09-05 | Last modified: | 2018-10-24 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1. Nat Microbiol, 3, 2018
|
|
2A19
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2a19 by Molmil](/molmil-images/mine/2a19) | PKR kinase domain- eIF2alpha- AMP-PNP complex. | Descriptor: | Eukaryotic translation initiation factor 2 alpha subunit, Interferon-induced, double-stranded RNA-activated protein kinase, ... | Authors: | Dar, A.C, Dever, T.E, Sicheri, F. | Deposit date: | 2005-06-19 | Release date: | 2005-09-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR. Cell(Cambridge,Mass.), 122, 2005
|
|
1WCM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1wcm by Molmil](/molmil-images/mine/1wcm) | Complete 12-Subunit RNA Polymerase II at 3.8 Angstrom | Descriptor: | DNA-DIRECTED RNA POLYMERASE II 13.6 KDA POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 14.2 KDA POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 19 KD POLYPEPTIDE, ... | Authors: | Armache, K.-J, Mitterweger, S, Meinhart, A, Cramer, P. | Deposit date: | 2004-11-17 | Release date: | 2004-12-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structures of Complete RNA Polymerase II and its Subcomplex,Rpb4/7 J.Biol.Chem., 280, 2005
|
|
2A1A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2a1a by Molmil](/molmil-images/mine/2a1a) | PKR kinase domain-eIF2alpha Complex | Descriptor: | Eukaryotic translation initiation factor 2 alpha subunit, Interferon-induced, double-stranded RNA-activated protein kinase | Authors: | Dar, A.C, Dever, T.E, Sicheri, F. | Deposit date: | 2005-06-19 | Release date: | 2005-09-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR. Cell(Cambridge,Mass.), 122, 2005
|
|
6O85
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6o85 by Molmil](/molmil-images/mine/6o85) | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic translation initiation factor 2 from Homo sapiens | Descriptor: | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, ... | Authors: | Nguyen, H.C, Kenner, L.R, Frost, A.S. | Deposit date: | 2019-03-08 | Release date: | 2019-05-15 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science, 364, 2019
|
|
6O81
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6o81 by Molmil](/molmil-images/mine/6o81) | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation initiation factor 2 from Homo sapiens | Descriptor: | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, ... | Authors: | Nguyen, H, Kenner, L, Frost, A. | Deposit date: | 2019-03-08 | Release date: | 2019-05-15 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science, 364, 2019
|
|