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2R3G	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 6-(2-fluorophenyl)-N-(pyridin-3-ylmethyl)imidazo[1,2-a]pyrazin-8-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3I	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 5-(2-fluorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3M	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: Cell division protein kinase 2, N-((2-aminopyrimidin-5-yl)methyl)-5-(2,6-difluorophenyl)-3-ethylpyrazolo[1,5-a]pyrimidin-7-amine Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3Q	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
6AC7	Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter Descriptor: 5'-D(*TP*GP*GP*GP*GP*TP*CP*CP*GP*AP*GP*GP*CP*GP*GP*GP*GP*CP*TP*TP*GP*GP*G)-3' Authors: Sengar, A, Vandana, J.J, Chambers, V.S, Di Antonio, M, Winnerdy, F.R, Balasubramanian, S, Phan, A.T. Deposit date: 2018-07-25 Release date: 2019-02-27 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter. Nucleic Acids Res., 47, 2019
2R3R	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 3-bromo-5-phenyl-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2021-07-28 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3H	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 3-methyl-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyrazin-8-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
6WNX	FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide Descriptor: Catenin beta-1, F-box/WD repeat-containing protein 11, GLYCEROL, ... Authors: Ivanochko, D, Edwards, A.M, Bountra, C, Arrowsmith, C.H, Boettcher, J, Structural Genomics Consortium (SGC) Deposit date: 2020-04-23 Release date: 2020-05-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide To Be Published
4F8C	Structure of the Cif:Nedd8 complex - Yersinia pseudotuberculosis Cycle Inhibiting Factor in complex with human Nedd8 Descriptor: 1,2-ETHANEDIOL, Cycle Inhibiting Factor, NEDD8 Authors: Crow, A, Banfield, M. Deposit date: 2012-05-17 Release date: 2012-06-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.95 Å) Cite: The molecular basis of Nedd8 deamidation by the bacterial effector protein Cif Proc.Natl.Acad.Sci.USA, 2012
2AST	Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide Descriptor: BENZAMIDINE, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, ... Authors: Hao, B, Zhang, N, Schulman, B.A, Wu, G, Pagano, M, Pavletich, N.P. Deposit date: 2005-08-24 Release date: 2005-10-18 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase. Mol.Cell, 20, 2005
2E31	Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase Descriptor: F-box only protein 2, S-phase kinase-associated protein 1A Authors: Mizushima, T, Yoshida, Y, Kumanomidou, T, Hasegawa, Y, Yamane, T, Tanaka, K. Deposit date: 2006-11-20 Release date: 2007-03-20 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for the selection of glycosylated substrates by SCFFbs1 ubiquitin ligase Proc.Natl.Acad.Sci.Usa, 104, 2007
2ASS	Crystal structure of the Skp1-Skp2-Cks1 complex Descriptor: BENZAMIDINE, Cyclin-dependent kinases regulatory subunit 1, PHOSPHATE ION, ... Authors: Hao, B, Zhang, N, Schulman, B.A, Wu, G, Pagano, M, Pavletich, N.P. Deposit date: 2005-08-24 Release date: 2005-10-18 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase. Mol.Cell, 20, 2005
2E32	Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase Descriptor: F-box only protein 2, S-phase kinase-associated protein 1A Authors: Mizushima, T, Yoshida, Y, Kumanomidou, T, Hasegawa, Y, Yamane, T, Tanaka, K. Deposit date: 2006-11-20 Release date: 2007-03-20 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.52 Å) Cite: Structural basis for the selection of glycosylated substrates by SCFFbs1 ubiquitin ligase Proc.Natl.Acad.Sci.Usa, 104, 2007
5IBK	Skp1-F-box in complex with a ubiquitin variant Descriptor: F-box/WD repeat-containing protein 7, Polyubiquitin-B, S-phase kinase-associated protein 1,S-phase kinase-associated protein 1 Authors: Orlicky, S, Sicheri, F. Deposit date: 2016-02-22 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.503 Å) Cite: Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface. Proc.Natl.Acad.Sci.USA, 113, 2016
2L7F	Solution Structure of the Pitx2 Homeodomain Descriptor: Pituitary homeobox 2 Authors: Doerdelmann, T, Rance, M, Baird-Titus, J.M, Kojetin, D.J. Deposit date: 2010-12-08 Release date: 2011-12-14 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution Structure of the Pitx2 Homeodomain To be Published
6HG9	Crystal Structure of the human IL-17RC ECD in complex with human IL-17F, Crystal form II Descriptor: Interleukin-17 receptor C, Interleukin-17F Authors: Rondeau, J.M, Goepfert, A. Deposit date: 2018-08-23 Release date: 2020-03-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.62 Å) Cite: Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling. Immunity, 52, 2020
6HG4	Crystal Structure of the human IL-17RC ECD in complex with human IL-17F Descriptor: Interleukin-17 receptor C, Interleukin-17F Authors: Rondeau, J.M, Goepfert, A. Deposit date: 2018-08-22 Release date: 2020-03-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.32 Å) Cite: Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling. Immunity, 52, 2020
8SV1	Caspase-1 complex with interleukin-18 Descriptor: Caspase-1, Interleukin-18 Authors: Dong, Y, Pascal, D, Jon, K, Wu, H. Deposit date: 2023-05-15 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Caspase-1 complex with interleukin-18 To Be Published
2L7M	Solution Structure of the Pitx2 Homeodomain R24H mutant Descriptor: Pituitary homeobox 2 Authors: Doerdelmann, T, Rance, M, Kojetin, D.J, Baird-Titus, J.M. Deposit date: 2010-12-14 Release date: 2011-12-14 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution Structure of the Pitx2 Homeodomain R24H mutant To be Published
2LKX	NMR structure of the homeodomain of Pitx2 in complex with a TAATCC DNA binding site Descriptor: DNA (5'-D(*CP*GP*GP*GP*GP*AP*TP*TP*AP*GP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*CP*TP*AP*AP*TP*CP*CP*CP*CP*G)-3'), Pituitary homeobox 3 Authors: Baird-Titus, J.M, Doerdelmann, T, Chaney, B.A, Clark-Baldwin, K, Dave, V, Ma, J. Deposit date: 2011-10-21 Release date: 2012-05-02 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution structure of the K50 class homeodomain PITX2 bound to DNA and implications for mutations that cause Rieger syndrome Biochemistry, 44, 2005
6H5H	A computationally designed dRP lyase domain reconstructed from two heterologous fragments Descriptor: polb4 Authors: ElGamacy, M, Coles, M, Lupas, A.N. Deposit date: 2018-07-24 Release date: 2018-12-12 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Asymmetric protein design from conserved supersecondary structures. J. Struct. Biol., 204, 2018
8BYL	Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex Descriptor: Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, S-phase kinase-associated protein 1, ... Authors: Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E.M. Deposit date: 2022-12-13 Release date: 2023-06-28 Last modified: 2023-07-19 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1. Sci Rep, 13, 2023
3L2O	Structure-Based Mechanism of Dimerization-Dependent Ubiquitination by the SCFFbx4 Ubiquitin Ligase Descriptor: F-box only protein 4, S-phase kinase-associated protein 1 Authors: Li, Y, Hao, B. Deposit date: 2009-12-15 Release date: 2010-02-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase. J.Biol.Chem., 285, 2010
1LDK	Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex Descriptor: CULLIN HOMOLOG, CYCLIN A/CDK2-ASSOCIATED PROTEIN P19, SKP2-like protein type gamma, ... Authors: Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P. Deposit date: 2002-04-08 Release date: 2002-05-08 Last modified: 2019-11-20 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature, 416, 2002
3BUY	MHC-I in complex with peptide Descriptor: Beta-2-microglobulin, H-2 class I histocompatibility antigen, D-B alpha chain, ... Authors: Rossjohn, J, La Gruta, N.L, Purcell, A.W, Turner, S.J, Dunstone, M.A. Deposit date: 2008-01-03 Release date: 2008-03-25 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides Proc.Natl.Acad.Sci.Usa, 105, 2008

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