2LKX

NMR structure of the homeodomain of Pitx2 in complex with a TAATCC DNA binding site

Replaces:  1YZ8

Summary for 2LKX

• Entry DOI: 10.2210/pdb2lkx/pdb
• NMR Information: BMRB: 18015
• Descriptor: Pituitary homeobox 3, DNA (5'-D(*GP*CP*TP*CP*TP*AP*AP*TP*CP*CP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*GP*GP*AP*TP*TP*AP*GP*AP*GP*C)-3') (3 entities in total)
• Functional Keywords: transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus (By similarity): O75364
• Total number of polymer chains: 3
• Total formula weight: 16430.71

Authors

Baird-Titus, J.M.,Doerdelmann, T.,Chaney, B.A.,Clark-Baldwin, K.,Dave, V.,Ma, J. (deposition date: 2011-10-21, release date: 2012-05-02)

• Primary citation: Chaney, B.A.,Clark-Baldwin, K.,Dave, V.,Ma, J.,Rance, M.; Solution structure of the K50 class homeodomain PITX2 bound to DNA and implications for mutations that cause Rieger syndrome; Biochemistry, 44:7497-7511, 2005; PubMed: 15895993; DOI: 10.1021/bi0473253

Experimental method

SOLUTION NMR