2LKX

NMR structure of the homeodomain of Pitx2 in complex with a TAATCC DNA binding site

Replaces:  1YZ8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
A	0003677	molecular_function	DNA binding
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. IAvwTnLTeaRVRVWFkNrrakwR

Chain	Residue	Details
A	ILE34-ARG57

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	59
Details	DNA_BIND: Homeobox => ECO:0000255|PROSITE-ProRule:PRU00108

Chain	Residue	Details
A	GLN1-GLU60

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKB/AKT2 => ECO:0000250

Chain	Residue	Details
A	THR6

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