8H40
 
 | | Cryo-EM structure of the transcription activation complex NtcA-TAC | | Descriptor: | DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. | | Deposit date: | 2022-10-09 | | Release date: | 2023-10-04 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | DNA looping mediates cooperative transcription activation.
Nat.Struct.Mol.Biol., 31, 2024
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1B5A
 | | RAT FERROCYTOCHROME B5 A CONFORMATION, NMR, 1 STRUCTURE | | Descriptor: | FERROCYTOCHROME B5, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Dangi, B, Sarma, S, Yan, C, Banville, D, Guiles, R.D. | | Deposit date: | 1998-04-06 | | Release date: | 1998-06-17 | | Last modified: | 2024-04-10 | | Method: | SOLUTION NMR | | Cite: | The origin of differences in the physical properties of the equilibrium forms of cytochrome b5 revealed through high-resolution NMR structures and backbone dynamic analyses.
Biochemistry, 37, 1998
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5LK8
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6OHJ
 | | Crystal Structure of the Debrominase Bmp8 C82A in Complex with 2,3,4-tribromopyrrole | | Descriptor: | 2,3,4-tribromo-1H-pyrrole, Debrominase Bmp8, SULFATE ION | | Authors: | Chekan, J.R, Moore, B.S. | | Deposit date: | 2019-04-05 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.19 Å) | | Cite: | Bacterial Tetrabromopyrrole Debrominase Shares a Reductive Dehalogenation Strategy with Human Thyroid Deiodinase.
Biochemistry, 58, 2019
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1MO7
 | | ATPase | | Descriptor: | Sodium/Potassium-transporting ATPase alpha-1 chain | | Authors: | Hilge, M, Siegal, G, Vuister, G.W, Guentert, P, Gloor, S.M, Abrahams, J.P. | | Deposit date: | 2002-09-08 | | Release date: | 2003-06-03 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | ATP-induced conformational changes of the nucleotide-binding domain of Na,K-ATPase
Nat.Struct.Biol., 10, 2003
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1LZL
 | | Bacterial Heroin Esterase | | Descriptor: | HEROIN ESTERASE | | Authors: | Zhu, X, Larsen, N.A, Basran, A, Bruce, N.C, Wilson, I.A. | | Deposit date: | 2002-06-10 | | Release date: | 2003-01-28 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | OBSERVATION OF AN ARSENIC ADDUCT IN AN ACETYL ESTERASE CRYSTAL STRUCTURE
J.Biol.Chem., 278, 2003
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5LG9
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5LH4
 | | Trypsin inhibitors for the treatment of pancreatitis - cpd 1 | | Descriptor: | (2~{S},4~{S})-1-[4-(aminomethyl)phenyl]carbonyl-4-(4-cyclopropyl-1,2,3-triazol-1-yl)-~{N}-(2,2-diphenylethyl)pyrrolidine-2-carboxamide, CALCIUM ION, Cationic trypsin, ... | | Authors: | Schiering, N, D'Arcy, A, Skaanderup, P, Simic, O, Brandl, T, Woelcke, J. | | Deposit date: | 2016-07-08 | | Release date: | 2018-01-17 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.37 Å) | | Cite: | Trypsin inhibitors for the treatment of pancreatitis.
Bioorg. Med. Chem. Lett., 26, 2016
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6ODL
 | | Crystal structure of GluN2A agonist binding domain with 4-butyl-(S)-CCG-IV | | Descriptor: | (1S,2R)-2-[(S)-amino(carboxy)methyl]-1-butylcyclopropane-1-carboxylic acid, Glutamate receptor ionotropic, NMDA 2A,Glutamate receptor ionotropic, ... | | Authors: | Mou, T.C, Clausen, R.P, Sprang, S.R, Hansen, K.B. | | Deposit date: | 2019-03-26 | | Release date: | 2020-04-01 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Stereoselective synthesis of novel 2'-(S)-CCG-IV analogues as potent NMDA receptor agonists.
Eur.J.Med.Chem., 212, 2021
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6O84
 | | Cryo-EM structure of OTOP3 from xenopus tropicalis | | Descriptor: | LOC100127796 protein,LOC100127796 protein,OTOP3,LOC100127796 protein,LOC100127796 protein | | Authors: | Chen, Q.F, Bai, X.C, Jiang, Y.X. | | Deposit date: | 2019-03-08 | | Release date: | 2019-04-24 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.92 Å) | | Cite: | Structural and functional characterization of an otopetrin family proton channel.
Elife, 8, 2019
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6O90
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6OFX
 | | Non-rotated ribosome (Structure I) | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Svidritskiy, E, Demo, G, Loveland, A.B, Xu, C, Korostelev, A.A. | | Deposit date: | 2019-04-01 | | Release date: | 2019-09-25 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Extensive ribosome and RF2 rearrangements during translation termination.
Elife, 8, 2019
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1MKD
 | | crystal structure of PDE4D catalytic domain and zardaverine complex | | Descriptor: | 6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE, MAGNESIUM ION, Phosphodiesterase 4D, ... | | Authors: | Lee, M.E, Markowitz, J, Lee, J.-O, Lee, H. | | Deposit date: | 2002-08-29 | | Release date: | 2003-03-01 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of phosphodiesterase 4D and inhibitor complex
FEBS LETT., 530, 2002
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6ON2
 | | Lon Protease from Yersinia pestis with Y2853 substrate | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent protease La, ... | | Authors: | Shin, M, Asmita, A, Puchades, C, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C. | | Deposit date: | 2019-04-19 | | Release date: | 2019-05-01 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis for distinct operational modes and protease activation in AAA+ protease Lon.
Sci Adv, 6, 2020
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5LK7
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6OT0
 | | Structure of human Smoothened-Gi complex | | Descriptor: | 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-OL, Fab heavy chain, Fab light chain, ... | | Authors: | Qi, X, Li, X. | | Deposit date: | 2019-05-02 | | Release date: | 2019-06-12 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.
Nature, 571, 2019
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6OQH
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2QKI
 | | Human C3c in complex with the inhibitor compstatin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, Complement C3, ... | | Authors: | Janssen, B.J.C, Halff, E.F, Lambris, J.D, Gros, P. | | Deposit date: | 2007-07-11 | | Release date: | 2007-08-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition.
J.Biol.Chem., 282, 2007
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6QTC
 | | tSH2 domain of transcription elongation factor Spt6 complexed with tyrosine phosphorylated CTD | | Descriptor: | Tyrosine phosphorylated CTD, tSH2 domain of transcription elongation factor Spt6 | | Authors: | Brazda, P, Krejcikova, M, Smirakova, E, Kubicek, K, Stefl, R. | | Deposit date: | 2019-02-24 | | Release date: | 2020-07-15 | | Last modified: | 2023-11-15 | | Method: | SOLUTION NMR | | Cite: | tSH2 domain of transcription elongation factor Spt6 complexed with tyrosine phosphorylated CTD
To Be Published
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7Y12
 | | Cryo-EM structure of MrgD-Gi complex with beta-alanine | | Descriptor: | BETA-ALANINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | | Deposit date: | 2022-06-06 | | Release date: | 2022-07-20 | | Last modified: | 2023-02-15 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM.
Commun Biol, 5, 2022
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5LQY
 | | Structure of F-ATPase from Pichia angusta, in state2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase OSCP subunit, ... | | Authors: | Vinothkumar, K.R, Montgomery, M.G, Liu, S, Walker, J.E. | | Deposit date: | 2016-08-17 | | Release date: | 2016-11-16 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (7.8 Å) | | Cite: | Structure of the mitochondrial ATP synthase fromPichia angustadetermined by electron cryo-microscopy.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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7Y15
 | | Cryo-EM structure of apo-state MrgD-Gi complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | | Deposit date: | 2022-06-06 | | Release date: | 2022-07-20 | | Last modified: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM.
Commun Biol, 5, 2022
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5LJ3
 | | Structure of the core of the yeast spliceosome immediately after branching | | Descriptor: | CEF1, CLF1, CWC15, ... | | Authors: | Galej, W.P, Wilkinson, M.F, Fica, S.M, Oubridge, C, Newman, A.J, Nagai, K. | | Deposit date: | 2016-07-17 | | Release date: | 2016-08-03 | | Last modified: | 2019-10-23 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Cryo-EM structure of the spliceosome immediately after branching.
Nature, 537, 2016
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8UGY
 | | Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Mianserin | | Descriptor: | 5-hydroxytryptamine receptor 1E, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zilberg, G, Warren, A.L, Wacker, D. | | Deposit date: | 2023-10-06 | | Release date: | 2024-05-01 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5-HT 1e R and 5-HT 1F R.
Sci Adv, 10, 2024
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7XTA
 | | Serotonin 4 (5-HT4) receptor-Gi-scFv16 complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. | | Deposit date: | 2022-05-16 | | Release date: | 2022-07-27 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
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